Linked Life Data

12824720

Source:http://linkedlifedata.com/resource/pubmed/id/12824720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-6-25
pubmed:abstractText
Rosuvastatin (Crestor; licensed to AstraZeneca, Macclesfield, UK from Shionogi, Osaka, Japan) is a new statin with pharmacologic characteristics that translate into selectivity of effect in hepatic cells and enhanced potency in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition. It is approved for use at doses of 10-40 mg once daily to reduce low-density lipoprotein (LDL) cholesterol, increase high-density lipoprotein (HDL) cholesterol and improve other lipid measures in dyslipidemic patients. In a dose-ranging study in mild/moderate hypercholesterolemia, rosuvastatin reduced LDL cholesterol by 52-63% at 10-40 mg. Rosuvastatin 10 mg reduces LDL cholesterol significantly more than atorvastatin 10 mg, simvastatin 10-40 mg and pravastatin 10-40 mg, and enables significantly more patients to achieve National Cholesterol Education Program and Joint European Societies LDL cholesterol goals compared with each of these statins. Rosuvastatin also produces marked elevations in HDL cholesterol and maintains this effect across the dose range. Rosuvastatin favorably modifies triglycerides, LDL cholesterol and other lipid measures in patients with hypertriglyceridemia or mixed dyslipidemia, including diabetic patients, and may constitute a monotherapy option for many such patients. Rosuvastatin is well tolerated when used alone or in combination, exhibiting a safety profile similar to that of other available statins. Rosuvastatin offers considerable advantages for use in routine clinical practice.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0008-6312
pubmed:author
pubmed:copyrightInfo
Copyright 2003 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-39
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12824720-Adult, pubmed-meshheading:12824720-Aged, pubmed-meshheading:12824720-Cholesterol, HDL, pubmed-meshheading:12824720-Cholesterol, LDL, pubmed-meshheading:12824720-Clinical Trials as Topic, pubmed-meshheading:12824720-Dose-Response Relationship, Drug, pubmed-meshheading:12824720-Drug Administration Schedule, pubmed-meshheading:12824720-Female, pubmed-meshheading:12824720-Fluorobenzenes, pubmed-meshheading:12824720-Follow-Up Studies, pubmed-meshheading:12824720-Humans, pubmed-meshheading:12824720-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:12824720-Hyperlipidemias, pubmed-meshheading:12824720-Male, pubmed-meshheading:12824720-Middle Aged, pubmed-meshheading:12824720-Pyrimidines, pubmed-meshheading:12824720-Sulfonamides, pubmed-meshheading:12824720-Treatment Outcome
pubmed:year
2003
pubmed:articleTitle
Rosuvastatin--a highly effective new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor: review of clinical trial data at 10-40 mg doses in dyslipidemic patients.
pubmed:affiliation
MDC, Humboldt University, Berlin, Germany.
pubmed:publicationType
Journal Article, Review