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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-6-17
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pubmed:abstractText |
Bone morphogenetic protein-7 (BMP-7) is a growth and differentiation factor and belongs to the TGF-beta superfamily of proteins. Previous studies have shown an abundant expression of BMP-7 in the developing intestine and an association with a perturbed BMP/SMAD downstream signaling leading to a malignant phenotype and inflammation in the gut. In the present study, we have evaluated the effect of systemically administered recombinant human BMP-7 against trinitrobenzenesulfonic (TNBS) acid induced inflammatory bowel disease (IBD) in rats. The TNBS administered rats treated with BMP-7 have developed much less severe form of colitis based on macroscopic and histological scoring when administered 1.5 h before or 24 h after colitis induction. Bioavailability studies in healthy rats have revealed that significant portion (3.6%) of i.v. administered BMP-7 is targeted for BMP-7 receptors in the stomach and ileum, respectively, suggesting its availability to target tissue upon administration. Immunohistochemical and RT-PCR analyses have shown elevated expression of pro-inflammatory (IL-6, TNF-beta, ICAM-1) and pro-fibrogenic (TGF-beta) cytokines, and BMP-7 treatment significantly reduced their expression in the intestine; among which the suppression of IL-6 appeared to be the most important. Taken together, the results of this study suggest that BMP-7 plays an important role in the regulation of anti-inflammatory response in the adult gut tissue.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ACVR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp7 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9541
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
258-64
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12811818-Activin Receptors, Type I,
pubmed-meshheading:12811818-Animals,
pubmed-meshheading:12811818-Bone Morphogenetic Protein 7,
pubmed-meshheading:12811818-Bone Morphogenetic Protein Receptors, Type I,
pubmed-meshheading:12811818-Bone Morphogenetic Proteins,
pubmed-meshheading:12811818-Colon,
pubmed-meshheading:12811818-Down-Regulation,
pubmed-meshheading:12811818-Humans,
pubmed-meshheading:12811818-Inflammatory Bowel Diseases,
pubmed-meshheading:12811818-Injections, Intravenous,
pubmed-meshheading:12811818-Intercellular Adhesion Molecule-1,
pubmed-meshheading:12811818-Interleukin-6,
pubmed-meshheading:12811818-Intestines,
pubmed-meshheading:12811818-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12811818-Proteins,
pubmed-meshheading:12811818-RNA, Messenger,
pubmed-meshheading:12811818-Rats,
pubmed-meshheading:12811818-Rats, Sprague-Dawley,
pubmed-meshheading:12811818-Receptors, Growth Factor,
pubmed-meshheading:12811818-Severity of Illness Index,
pubmed-meshheading:12811818-Stomach,
pubmed-meshheading:12811818-Time Factors,
pubmed-meshheading:12811818-Transforming Growth Factor beta,
pubmed-meshheading:12811818-Transforming Growth Factor beta1,
pubmed-meshheading:12811818-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12811818-Wound Healing
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pubmed:year |
2003
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pubmed:articleTitle |
Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats.
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pubmed:affiliation |
Department of Anatomy, Medical School University of Rijeka, Croatia.
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pubmed:publicationType |
Journal Article
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