| pubmed-article:1279482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C0032433 | lld:lifeskim |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C1152805 | lld:lifeskim |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:1279482 | lifeskim:mentions | umls-concept:C0112201 | lld:lifeskim |
| pubmed-article:1279482 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:1279482 | pubmed:dateCreated | 1992-12-18 | lld:pubmed |
| pubmed-article:1279482 | pubmed:abstractText | Receptor binding assays have shown that diaminodecane (DA-10) reduced binding of open channel blockers to the N-methyl-D-aspartate (NMDA) subtype of postsynaptic glutamate receptor through an interaction with the polyamine regulatory site. Because the action of DA-10 was opposite to that of the polyamine agonist spermine and was reversed by polyamine antagonists, DA-10 has been classified as an inverse agonist at the polyamine site. Using whole-cell voltage-clamp and single-channel recordings from cultured rat cortical neurons, we show that at negative holding potentials DA-10 (1-300 microM) reduced NMDA receptor whole cell current (IC50 = 34 microM) and produced a flickery block of NMDA single-channel currents. The flickery block of NMDA single channels was voltage-dependent and not reversed by the polyamine antagonist diethylenetriamine (DET). Potential mechanisms for the flickery block of NMDA single channel currents are discussed. | lld:pubmed |
| pubmed-article:1279482 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1279482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1279482 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1279482 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:1279482 | pubmed:author | pubmed-author:MacdonaldR... | lld:pubmed |
| pubmed-article:1279482 | pubmed:author | pubmed-author:RuleB FBF | lld:pubmed |
| pubmed-article:1279482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1279482 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:1279482 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:1279482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1279482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1279482 | pubmed:pagination | 111-5 | lld:pubmed |
| pubmed-article:1279482 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
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| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:meshHeading | pubmed-meshheading:1279482-... | lld:pubmed |
| pubmed-article:1279482 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1279482 | pubmed:articleTitle | The polyamine diaminodecane (DA-10) produces a voltage-dependent flickery block of single NMDA receptor channels. | lld:pubmed |
| pubmed-article:1279482 | pubmed:affiliation | Neuroscience Program, University of Michigan, Ann Arbor. | lld:pubmed |
| pubmed-article:1279482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1279482 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1279482 | lld:pubmed |
