| pubmed-article:12792868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C0205466 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C1136169 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C1963724 | lld:lifeskim |
| pubmed-article:12792868 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12792868 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12792868 | pubmed:dateCreated | 2003-6-6 | lld:pubmed |
| pubmed-article:12792868 | pubmed:abstractText | T cell dynamics and viral genotype were studied in human immunodeficiency virus 1-infected individuals receiving antiretroviral therapy who were viremic and had either increasing (discordant immunological responders) or decreasing (nonresponders) CD4(+) T cell counts. A comparison was made with treated individuals who were not viremic and had increasing CD4(+) T cell counts (complete responders). Nonresponders had higher CD4(+) T cell proliferation (as assessed by Ki67 expression) and immune activation (as assessed by CD38 and human leukocyte antigen-DR expression), together with a reduction in T cell receptor excision circles, compared with discordant immunological responders and complete responders, which suggests that there is enhanced viral pathogenicity in both peripheral T cells and the thymus. Although there was a high prevalence of mutations in the protease and reverse transcriptase genes in discordant immunological responders, these changes were also observed in nonresponders. | lld:pubmed |
| pubmed-article:12792868 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12792868 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792868 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12792868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12792868 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12792868 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:LewinSharon... | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:CroweSuzanne... | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:BaileyMichael... | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:CameronPaul... | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:SolomonAjanth... | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:DunneAmanda... | lld:pubmed |
| pubmed-article:12792868 | pubmed:author | pubmed-author:HoyJenny FJF | lld:pubmed |
| pubmed-article:12792868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12792868 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12792868 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:12792868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12792868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12792868 | pubmed:pagination | 1915-23 | lld:pubmed |
| pubmed-article:12792868 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:meshHeading | pubmed-meshheading:12792868... | lld:pubmed |
| pubmed-article:12792868 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12792868 | pubmed:articleTitle | Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicity. | lld:pubmed |
| pubmed-article:12792868 | pubmed:affiliation | Department of Microbiology and Immunology, University of Melbourne, and Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia. | lld:pubmed |
| pubmed-article:12792868 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12792868 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12792868 | lld:pubmed |
