| pubmed-article:1279206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0030657 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0680063 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0019691 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:1279206 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:1279206 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1279206 | pubmed:dateCreated | 1992-12-15 | lld:pubmed |
| pubmed-article:1279206 | pubmed:abstractText | Levels of human immunodeficiency virus (HIV) DNA, RNA, or p24 antigen and reverse transcriptase activity in T-cell cultures treated with 500 IU of recombinant alpha interferon (rIFN alpha) per ml were comparable to those in control cultures. Radioimmunoprecipitation analysis of proteins in lysates of IFN-treated T cells documented a marked accumulation of HIV proteins. Localization of gp120 by immunofluorescence showed a diffuse pattern in IFN-treated cells quite distinct from the ring pattern in untreated control cells. That large quantities of gp120 in aberrant cell compartments might affect HIV morphogenesis was confirmed in infectivity studies: virions from IFN-treated cells were 100- to 1,000-fold less infectious than an equal number of virions from control cells. Direct examination of IFN-treated and control HIV-infected cells by transmission electron microscopy showed little difference in the number or distribution of viral particles. However, quantitation of gp120 by immunogold particle analysis revealed a marked depletion of envelope glycoprotein in virions released from IFN-treated cells. This defect in gp120 assembly onto mature viral particles provides a molecular basis for this loss of infectivity. | lld:pubmed |
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| pubmed-article:1279206 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1279206 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1279206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1279206 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1279206 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:MaheshwariR... | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:SidhuG SGS | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:MeltzerM SMS | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:HansenB DBD | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:NaraP LPL | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:GendelmanH... | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:BernbaumJ GJG | lld:pubmed |
| pubmed-article:1279206 | pubmed:author | pubmed-author:HoekzemaDD | lld:pubmed |
| pubmed-article:1279206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1279206 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1279206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1279206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1279206 | pubmed:pagination | 7543-8 | lld:pubmed |
| pubmed-article:1279206 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:1279206 | pubmed:meshHeading | pubmed-meshheading:1279206-... | lld:pubmed |
| pubmed-article:1279206 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1279206 | pubmed:articleTitle | Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120. | lld:pubmed |
| pubmed-article:1279206 | pubmed:affiliation | Department of Cellular Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100. | lld:pubmed |
| pubmed-article:1279206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1279206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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