| pubmed-article:12778478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12778478 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:12778478 | lifeskim:mentions | umls-concept:C1326202 | lld:lifeskim |
| pubmed-article:12778478 | lifeskim:mentions | umls-concept:C0332162 | lld:lifeskim |
| pubmed-article:12778478 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:12778478 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12778478 | pubmed:dateCreated | 2003-6-2 | lld:pubmed |
| pubmed-article:12778478 | pubmed:abstractText | To investigate whether the increased rate of lymphocyte apoptosis in systemic lupus erythematosus is involved in the onset of the disease, apoptotic or necrotic T or B lymphocytes from various cell lines were injected intraperitoneally into pre-autoimmune (NZBxNZW)F1 mice (BW) and non-autoimmune BALB/c mice. The intraperitoneal production of cytokines and chemokines, the specific T cell response in the spleen, and the production of anti-histone and anti-dsDNA Ab were investigated. The onset of the disease was characterized by creatinine levels and evaluation of glomerular IgG deposits. In BW, but not in BALB/c mice, injection of apoptotic and not necrotic cells up-regulated IL-6 and IL-10 in resident macrophages. Administration of apoptotic cells augmented the number of Th2 and B lymphocytes recruited in the peritoneal cavity. Only the treatment with apoptotic B cells promoted a systemic Th2 autoimmune response to H2 histones, associated with earlier occurrence of high levels of anti-dsDNA autoantibodies, higher creatinine levels and more numerous glomerular IgG deposits than in BW controls not injected with apoptotic B cells. In genetically susceptible mice exposure to apoptotic of B, but not T, lymphocytes can elicit a Th2 response to H2 histones that helps B cell production of anti-dsDNA Ab and finally triggers the onset of lupus. | lld:pubmed |
| pubmed-article:12778478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12778478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12778478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12778478 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12778478 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:12778478 | pubmed:author | pubmed-author:WeillBernardB | lld:pubmed |
| pubmed-article:12778478 | pubmed:author | pubmed-author:FournierCathe... | lld:pubmed |
| pubmed-article:12778478 | pubmed:author | pubmed-author:BatteuxFrédér... | lld:pubmed |
| pubmed-article:12778478 | pubmed:author | pubmed-author:Trébéden-Nègr... | lld:pubmed |
| pubmed-article:12778478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12778478 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12778478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12778478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12778478 | pubmed:pagination | 1603-12 | lld:pubmed |
| pubmed-article:12778478 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:meshHeading | pubmed-meshheading:12778478... | lld:pubmed |
| pubmed-article:12778478 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12778478 | pubmed:articleTitle | B cell apoptosis accelerates the onset of murine lupus. | lld:pubmed |
| pubmed-article:12778478 | pubmed:affiliation | Laboratoire d'Immunologie, Hôpital et Faculté de Médecine Cochin, AP-HP, Université Paris V, France. | lld:pubmed |
| pubmed-article:12778478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12778478 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12778478 | lld:pubmed |
