| pubmed-article:12775554 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0041200 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0332298 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12775554 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:12775554 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12775554 | pubmed:dateCreated | 2003-8-11 | lld:pubmed |
| pubmed-article:12775554 | pubmed:abstractText | beta-Adrenoceptors (beta-ARs) are seven-transmembrane domain, G protein-coupled receptors that transduce the cellular effects of epinephrine and norepinephrine and play a pivotal role in the vertebrate stress response. This study reports the cloning and characterization of two previously unreported beta-ARs from the rainbow trout (Oncorhynchus mykiss). Phylogenetic analysis of amino acid sequences indicates that both beta-ARs are homologs of the mammalian beta3-AR. Analysis of tissue expression patterns indicates that one of these trout beta3-adrenoceptors (beta3a-AR) is highly expressed in gill and heart, whereas the second (beta3b-AR) is highly expressed by red blood cells (RBC). Expression of the beta3b-AR in the RBC coupled with the finding of a single category of beta-AR binding sites on RBC membranes provides strong evidence for the control of the trout RBC beta-AR Na+/H+ exchanger (beta-NHE) activity by signaling through this beta3b-subtype and not through a beta1-subtype as previously proposed. The RBC-specific trout beta3b-AR exhibits binding characteristics that distinguish this receptor from each of the three pharmacologically defined categories of mammalian beta-ARs (beta1-, beta2-, and beta3-AR). This study is the first to report the presence of a beta3-AR subtype in a fish species, and the proposal that the beta3b-AR controls RBC beta-NHE activity represents a novel role for the beta3-AR subtype in vertebrates. | lld:pubmed |
| pubmed-article:12775554 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12775554 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12775554 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12775554 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12775554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12775554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12775554 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12775554 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12775554 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:12775554 | pubmed:author | pubmed-author:DrouinGuyG | lld:pubmed |
| pubmed-article:12775554 | pubmed:author | pubmed-author:PerrySteve... | lld:pubmed |
| pubmed-article:12775554 | pubmed:author | pubmed-author:MoonThomas... | lld:pubmed |
| pubmed-article:12775554 | pubmed:author | pubmed-author:NickersonJame... | lld:pubmed |
| pubmed-article:12775554 | pubmed:author | pubmed-author:DuganStephen... | lld:pubmed |
| pubmed-article:12775554 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12775554 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:12775554 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12775554 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12775554 | pubmed:pagination | R526-35 | lld:pubmed |
| pubmed-article:12775554 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:meshHeading | pubmed-meshheading:12775554... | lld:pubmed |
| pubmed-article:12775554 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12775554 | pubmed:articleTitle | Activity of the unique beta-adrenergic Na+/H+ exchanger in trout erythrocytes is controlled by a novel beta3-AR subtype. | lld:pubmed |
| pubmed-article:12775554 | pubmed:affiliation | Dept. of Biology, Univ. of Ottawa, 150 Louis Pasteur, PO Box 450, Station A Ottawa, Ontario, Canada K1N 6N5. | lld:pubmed |
| pubmed-article:12775554 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12775554 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:100136173 | entrezgene:pubmed | pubmed-article:12775554 | lld:entrezgene |
| entrez-gene:100136655 | entrezgene:pubmed | pubmed-article:12775554 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12775554 | lld:pubmed |
