12774959

Source:http://linkedlifedata.com/resource/pubmed/id/12774959

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019202, umls-concept:C0114838, umls-concept:C1167622
pubmed:issue	2
pubmed:dateCreated	2003-5-30
pubmed:abstractText	In Wilson's disease (WD), brain magnetic resonance images (MRI) show increased signal intensity in T2 weighted images in the lenticular nuclei, thalamus and brainstem, including the substantia nigra. A poor therapeutic response to levodopa in WD suggests the mechanism of a postsynaptic abnormality. However positron emission tomography studies show an involvement of the nigrostriatal presynaptic dopaminergic pathway.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0415227
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Organotechnetium Compounds, http://linkedlifedata.com/resource/pubmed/chemical/SLC6A3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tropanes, http://linkedlifedata.com/resource/pubmed/chemical/technetium Tc 99m TRODAT-1
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0317-1671
pubmed:author	pubmed-author:ChuNai-ShinNS, pubmed-author:HuangChin-ChangCC, pubmed-author:LuChin-SongCS, pubmed-author:WaiYau-YauYY, pubmed-author:YenTzu-ChenTC
pubmed:issnType	Print
pubmed:volume	30
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	163-7
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12774959-Adult, pubmed-meshheading:12774959-Basal Ganglia, pubmed-meshheading:12774959-Dopamine, pubmed-meshheading:12774959-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:12774959-Female, pubmed-meshheading:12774959-Hepatolenticular Degeneration, pubmed-meshheading:12774959-Humans, pubmed-meshheading:12774959-Magnetic Resonance Imaging, pubmed-meshheading:12774959-Membrane Glycoproteins, pubmed-meshheading:12774959-Membrane Transport Proteins, pubmed-meshheading:12774959-Muscle Rigidity, pubmed-meshheading:12774959-Nerve Tissue Proteins, pubmed-meshheading:12774959-Neural Pathways, pubmed-meshheading:12774959-Organotechnetium Compounds, pubmed-meshheading:12774959-Presynaptic Terminals, pubmed-meshheading:12774959-Protein Binding, pubmed-meshheading:12774959-Substantia Nigra, pubmed-meshheading:12774959-Tomography, Emission-Computed, Single-Photon, pubmed-meshheading:12774959-Tropanes
pubmed:year	2003
pubmed:articleTitle	Dopamine transporter binding in Wilson's disease.
pubmed:affiliation	Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan.
pubmed:publicationType	Journal Article, Case Reports, Research Support, Non-U.S. Gov't