| pubmed-article:12706063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12706063 | lifeskim:mentions | umls-concept:C0034063 | lld:lifeskim |
| pubmed-article:12706063 | lifeskim:mentions | umls-concept:C0032227 | lld:lifeskim |
| pubmed-article:12706063 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12706063 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12706063 | pubmed:dateCreated | 2003-4-22 | lld:pubmed |
| pubmed-article:12706063 | pubmed:abstractText | We investigated the contribution of alpha- and beta-adrenergic pathways to catecholamine-induced pulmonary edema and the role of pleural effusion in preventing alveolar edema. Female Sprague-Dawley rats received continuous intravenous infusion of norepinephrine and of separate alpha- or beta-adrenergic stimulation over 6-24 h. We performed heart catheterization in vivo and excised post mortem lung tissue for histological analysis. Interleukin (IL)-6 and total protein concentrations were determined in serum, pleural fluid (PF) and bronchoalveolar lavage fluid. alpha-Adrenergic treatment increased right ventricular systolic pressure (RVSP) and total peripheral resistance (TPR) and caused severe alveolar edema associated with IL-6 activation in serum and diffuse pulmonary inflammation. PF amounts were moderate (0.9+/-0.2 ml). beta-Adrenergic stimulation also increased RVSP but decreased TPR. Interstitial but not alveolar edema and focal inflammation without IL-6 activation developed. Large PF amounts (6.2+/-1.5 ml) occurred which were considered to prevent alveolar edema. We conclude that both alpha- and beta-adrenergic stimulation contribute to pulmonary fluid shifts in rats, but alpha-adrenergic pathways cause more acute and more severe lung injury than beta-adrenergic mechanisms. | lld:pubmed |
| pubmed-article:12706063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12706063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12706063 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12706063 | pubmed:issn | 1569-9048 | lld:pubmed |
| pubmed-article:12706063 | pubmed:author | pubmed-author:TannapfelAndr... | lld:pubmed |
| pubmed-article:12706063 | pubmed:author | pubmed-author:BriestWilfrie... | lld:pubmed |
| pubmed-article:12706063 | pubmed:author | pubmed-author:RasslerBeateB | lld:pubmed |
| pubmed-article:12706063 | pubmed:author | pubmed-author:ReissigChrist... | lld:pubmed |
| pubmed-article:12706063 | pubmed:author | pubmed-author:ZimmerHeinz... | lld:pubmed |
| pubmed-article:12706063 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12706063 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12706063 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:12706063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12706063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12706063 | pubmed:pagination | 25-37 | lld:pubmed |
| pubmed-article:12706063 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12706063 | pubmed:meshHeading | pubmed-meshheading:12706063... | lld:pubmed |
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| pubmed-article:12706063 | pubmed:meshHeading | pubmed-meshheading:12706063... | lld:pubmed |
| pubmed-article:12706063 | pubmed:meshHeading | pubmed-meshheading:12706063... | lld:pubmed |
| pubmed-article:12706063 | pubmed:meshHeading | pubmed-meshheading:12706063... | lld:pubmed |
| pubmed-article:12706063 | pubmed:meshHeading | pubmed-meshheading:12706063... | lld:pubmed |
| pubmed-article:12706063 | pubmed:meshHeading | pubmed-meshheading:12706063... | lld:pubmed |
| pubmed-article:12706063 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12706063 | pubmed:articleTitle | Catecholamine-induced pulmonary edema and pleural effusion in rats--alpha- and beta-adrenergic effects. | lld:pubmed |
| pubmed-article:12706063 | pubmed:affiliation | Carl-Ludwig-Institute of Physiology, Liebigstr. 27, D-04103, Leipzig, Germany. rsb@medizin.uni-leipzig.de | lld:pubmed |
| pubmed-article:12706063 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12706063 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12706063 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
