Linked Life Data

12705719

Source:http://linkedlifedata.com/resource/pubmed/id/12705719

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-22
pubmed:abstractText
Male Wistar rats were exposed to pseudocumene vapors at nominal concentration of 25, 100 or 250 ppm in the dynamic inhalation chambers for 6 h or 4 weeks (6 h/day; 5 days/week). Following the inhalation exposure, pseudocumene concentrations were estimated in the brain, liver and lung homogenates, as well as in the brain (brainstem, hippocampus, temporal cortex, cerebellum) and blood (arterial, venous) structures. To estimate pseudocumene concentrations in biological material gas chromatography using the headspace technique was applied. The elimination of pseudocumene from venous blood after repeated inhalation exposures followed an open two-compartment model. Venous blood concentration was about twice as high as that in arterial blood. In tissues, the highest values were found in the liver after single exposure to pseudocumene vapor at concentrations of 100 and 250 ppm. There were no statistically significant differences in pseudocumene concentrations between the brain, lungs or arterial blood. In the brain structures of the animals exposed to pseudocumene vapors, significantly higher concentration of psedocumene was found in the brainstem.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1232-1087
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Pseudocumene in brain, liver, lung and blood of rats after single and repeated inhalation exposure.
pubmed:affiliation
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lód?, Poland. radek@imp.lodz.pl
pubmed:publicationType
Journal Article