Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-4-17
pubmed:abstractText
Exogenous or inhaled NO (iNO) has been successfully used, as a selective pulmonary vasodilator, in a wide variety of clinical situations especially in the management of persistent pulmonary hypertension in the newborn. A better understanding of the role of endogenous and exogenous NO in the lungs of surfactant-deficient animals exposed to hyperoxia could result in novel strategies for the better management of RDS in premature babies with the ultimate aim to decrease chronic lung disease in these infants. This review will focus on the effects of NO, when used in combination with hyperoxia, on lung injury; information on the effects on cell culture systems and animal models will be used to highlight the unique responses of the developing lung. Most of the data from cell culture systems and adult animal models of hyperoxia-induced lung injury suggests that endogenous NO has a protective role. In the newborn animal, endogenous NO appeared to be harmful, had no effect or was protective in hyperoxia-induced lung injury. The data are conflicting on the issue of whether exogenous NO is protective or damaging in the presence of hyperoxia on lung cells and animal models. Despite the variability in the studies, it would appear that low dose exogenous NO for short duration is beneficial in hyperoxic lung injury in adult and newborn animals. In the human newborn, use of iNO in infants< 34 weeks of gestation should be considered experimental, pending results of ongoing trials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e361-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The role of nitric oxide in hyperoxia-induced injury to the developing lung.
pubmed:affiliation
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, Children's Hospital, New Haven, CT 06520-8064, USA. vineet.bhandari@yale.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't