| pubmed-article:12695286 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12695286 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:12695286 | lifeskim:mentions | umls-concept:C0003811 | lld:lifeskim |
| pubmed-article:12695286 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:12695286 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:12695286 | lifeskim:mentions | umls-concept:C0205313 | lld:lifeskim |
| pubmed-article:12695286 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:12695286 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:12695286 | pubmed:dateCreated | 2003-5-6 | lld:pubmed |
| pubmed-article:12695286 | pubmed:abstractText | Many long-QT syndrome (LQTS) mutations in the cardiac Na+ channel result in a gain of function due to a fraction of channels that fail to inactivate (burst), leading to sustained current (Isus) during depolarization. However, some Na+ channel mutations that are causally linked to cardiac arrhythmia do not result in an obvious gain of function as measured using standard patch-clamp techniques. An example presented here, the SCN5A LQTS mutant I1768V, does not act to increase Isus (<0.1% of peak) compared with wild-type (WT) channels. In fact, it is difficult to reconcile the seemingly innocuous kinetic alterations in I1768V as measured during standard protocols under steady-state conditions with the disease phenotype. | lld:pubmed |
| pubmed-article:12695286 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12695286 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12695286 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12695286 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12695286 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12695286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12695286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12695286 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12695286 | pubmed:month | May | lld:pubmed |
| pubmed-article:12695286 | pubmed:issn | 1524-4539 | lld:pubmed |
| pubmed-article:12695286 | pubmed:author | pubmed-author:KassRobert... | lld:pubmed |
| pubmed-article:12695286 | pubmed:author | pubmed-author:TateyamaMichi... | lld:pubmed |
| pubmed-article:12695286 | pubmed:author | pubmed-author:WehrensXander... | lld:pubmed |
| pubmed-article:12695286 | pubmed:author | pubmed-author:ClancyColleen... | lld:pubmed |
| pubmed-article:12695286 | pubmed:author | pubmed-author:LiuHuajunH | lld:pubmed |
| pubmed-article:12695286 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12695286 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:12695286 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:12695286 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12695286 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12695286 | pubmed:pagination | 2233-7 | lld:pubmed |
| pubmed-article:12695286 | pubmed:dateRevised | 2011-7-22 | lld:pubmed |
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| pubmed-article:12695286 | pubmed:meshHeading | pubmed-meshheading:12695286... | lld:pubmed |
| pubmed-article:12695286 | pubmed:meshHeading | pubmed-meshheading:12695286... | lld:pubmed |
| pubmed-article:12695286 | pubmed:meshHeading | pubmed-meshheading:12695286... | lld:pubmed |
| pubmed-article:12695286 | pubmed:meshHeading | pubmed-meshheading:12695286... | lld:pubmed |
| pubmed-article:12695286 | pubmed:meshHeading | pubmed-meshheading:12695286... | lld:pubmed |
| pubmed-article:12695286 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12695286 | pubmed:articleTitle | Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. | lld:pubmed |
| pubmed-article:12695286 | pubmed:affiliation | Department of Pharmacology, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA. | lld:pubmed |
| pubmed-article:12695286 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12695286 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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