Linked Life Data

12687375

Source:http://linkedlifedata.com/resource/pubmed/id/12687375

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-6-11
pubmed:abstractText
Expiratory neurones, with a decrementing firing pattern during the first phase of expiration (E-DEC) and located in the rostral ventrolateral medulla, are thought to be involved in the network generating respiratory rhythm, which also includes expiratory neurones with augmenting firing patterns (E-AUG). We used cross-correlation to detect their synaptic interconnections and connections to phrenic motoneurones in 32 vagotomised, decerebrate, paralysed and ventilated male rats. Pairs of neurones were recorded extracellularly with glass-insulated tungsten microelectrodes and the whole phrenic nerve with bipolar silver wire electrodes. Of the 79 cross-correlograms computed between pairs of E-DEC neurones, 8 (approximately 10%) showed evidence for inhibitory connections. Of the 67 cross-correlograms computed between E-DEC and E-AUG neurones, 5 (7.5%) showed evidence for a monosynaptic inhibition of the E-AUG neurone by the E-DEC neurone, while 3 (4.5%) showed evidence for a monosynaptic inhibition of the E-DEC neurone by the E-AUG neurone. An inhibitory connection from E-DEC neurones to phrenic motoneurones was detected in 5 (approximately 2%) of the cross-correlograms, and from E-AUG neurones to phrenic motoneurones in 4 (approximately 3.7%). These results are the first demonstration that network models of rhythm generation in the rat involving reciprocal inhibition between E-DEC and E-AUG neurones could have a neurophysiological basis, and the first to demonstrate that phrenic motoneurones are inhibited during the early phase of expiration by E-DEC neurones.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
446
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Inhibitory connections among rostral medullary expiratory neurones detected with cross-correlation in the decerebrate rat.
pubmed:affiliation
Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't