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pubmed-article:12686390pubmed:abstractTextThe availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.lld:pubmed
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pubmed-article:12686390pubmed:articleTitlePrenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.lld:pubmed
pubmed-article:12686390pubmed:affiliationNeurobiology Research Laboratory, VA Medical Center, 27705, Durham, NC, USA.lld:pubmed
pubmed-article:12686390pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12686390pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:12686390pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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