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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
2003-5-9
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pubmed:abstractText |
Presentation of peptide epitopes derived from beta-cell autoantigens, such as insulin and its precursor molecules, by MHC class II molecules to autoreactive T-cells is believed to play a role in the development of Type 1 diabetes. However, little is known about the interaction between peptides of (prepro)insulin and MHC class II molecules permissive and protective for Type 1 diabetes. In this study therefore, peptides spanning the human preproinsulin sequence were assessed for their binding characteristics to Type 1 diabetes-protective and -permissive HLA molecules.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0012-186X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-503
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12684749-Diabetes Mellitus, Type 1,
pubmed-meshheading:12684749-Disease Susceptibility,
pubmed-meshheading:12684749-HLA-DQ Antigens,
pubmed-meshheading:12684749-HLA-DR2 Antigen,
pubmed-meshheading:12684749-HLA-DR4 Antigen,
pubmed-meshheading:12684749-Histocompatibility Antigens Class II,
pubmed-meshheading:12684749-Humans,
pubmed-meshheading:12684749-Proinsulin,
pubmed-meshheading:12684749-Protein Binding,
pubmed-meshheading:12684749-Protein Precursors
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pubmed:year |
2003
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pubmed:articleTitle |
Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules.
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pubmed:affiliation |
Department of Immunology, Guy's, King's and St. Thomas' School of Medicine, 123 Coldharbour Lane, SE5 9NU, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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