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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-2
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pubmed:abstractText |
Transgenic mice that express human tumor necrosis factor-alpha (Tg197 h-TNF-alpha) develop polyarthritis at 3 to 4 weeks of age leading to severe joint destruction at 8 to 10 weeks of age. Studies have suggested that inducible nitric oxide synthase (iNOS) activity can modulate the progression of arthritis. We investigated the induction of iNOS together with argininosuccinate synthase (AS) and GTP cyclohydrolase I (GTPCH), 2 of the rate-limiting enzymes for high output NO generation, in the Tg197 h-TNF-alpha transgenic model of arthritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Argininosuccinate Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Cyclohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxynitrous Acid,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
652-9
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:12672181-Animals,
pubmed-meshheading:12672181-Argininosuccinate Synthase,
pubmed-meshheading:12672181-Arthritis,
pubmed-meshheading:12672181-GTP Cyclohydrolase,
pubmed-meshheading:12672181-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12672181-Humans,
pubmed-meshheading:12672181-Mice,
pubmed-meshheading:12672181-Mice, Inbred C57BL,
pubmed-meshheading:12672181-Mice, Inbred CBA,
pubmed-meshheading:12672181-Mice, Transgenic,
pubmed-meshheading:12672181-Nitrates,
pubmed-meshheading:12672181-Nitric Oxide Synthase,
pubmed-meshheading:12672181-Nitric Oxide Synthase Type II,
pubmed-meshheading:12672181-Nitrites,
pubmed-meshheading:12672181-Oxidative Stress,
pubmed-meshheading:12672181-Penetrance,
pubmed-meshheading:12672181-Peroxynitrous Acid,
pubmed-meshheading:12672181-Phenotype,
pubmed-meshheading:12672181-RNA, Messenger,
pubmed-meshheading:12672181-Synovial Membrane,
pubmed-meshheading:12672181-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12672181-Tyrosine
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pubmed:year |
2003
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pubmed:articleTitle |
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
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pubmed:affiliation |
Institute of Biomedicine/Anatomy, Biomedicum Helsinki, University of Helsinki and ORTON Research Institute, Orthopaedic Hospital of the Invalid Foundation, Finland. mika.hukkanen@helsinki.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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