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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-28
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pubmed:abstractText |
Neonatal female rat pups that were raised artificially on a high-carbohydrate (HC) milk formula during their suckling period developed hyperinsulinemia immediately, maintained chronic hyperinsulinemia in the postweaning period on laboratory diet, and developed obesity in adulthood. Pups (second-generation HC [2-HC]) born to such female rats (first-generation HC [1-HC]) spontaneously developed chronic hyperinsulinemia and adult-onset obesity (HC phenotype) without the requirement for any dietary intervention in their suckling period. Leftward shift in the insulin secretory response to a glucose stimulus, increase in hexokinase activity, and increased preproinsulin gene transcription were observed in islets from 28-day-old 2-HC rats, and these adaptations are similar to those reported for islets from 12-day-old and 100-day-old 1-HC rats. Unlike 1-HC islets, the ability to secrete moderate amounts of insulin in the absence of glucose and calcium and the incretin input for augmentation of insulin secretion were not observed in 2-HC islets. These results show that a dietary modification in the early postnatal life of the 1-HC female rat sets up a vicious cycle of spontaneous transfer of the HC phenotype to its progeny, implicating a new component to the growing list of factors that contribute to the fetal origins of adult-onset diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Glucokinase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hexokinase,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Proinsulin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/preproinsulin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
984-90
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12663470-Animals,
pubmed-meshheading:12663470-Animals, Newborn,
pubmed-meshheading:12663470-Animals, Suckling,
pubmed-meshheading:12663470-Calcium,
pubmed-meshheading:12663470-Diet,
pubmed-meshheading:12663470-Dietary Carbohydrates,
pubmed-meshheading:12663470-Fatty Acids, Nonesterified,
pubmed-meshheading:12663470-Female,
pubmed-meshheading:12663470-Gene Expression Regulation,
pubmed-meshheading:12663470-Glucokinase,
pubmed-meshheading:12663470-Glucose,
pubmed-meshheading:12663470-Hexokinase,
pubmed-meshheading:12663470-Hyperinsulinism,
pubmed-meshheading:12663470-Insulin,
pubmed-meshheading:12663470-Islets of Langerhans,
pubmed-meshheading:12663470-Milk,
pubmed-meshheading:12663470-Obesity,
pubmed-meshheading:12663470-Phenotype,
pubmed-meshheading:12663470-Pregnancy,
pubmed-meshheading:12663470-Prenatal Exposure Delayed Effects,
pubmed-meshheading:12663470-Proinsulin,
pubmed-meshheading:12663470-Protein Precursors,
pubmed-meshheading:12663470-RNA, Messenger,
pubmed-meshheading:12663470-Rats,
pubmed-meshheading:12663470-Rats, Sprague-Dawley,
pubmed-meshheading:12663470-Transcription, Genetic,
pubmed-meshheading:12663470-Weaning
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pubmed:year |
2003
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pubmed:articleTitle |
Programming of islet functions in the progeny of hyperinsulinemic/obese rats.
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pubmed:affiliation |
Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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