Source:http://linkedlifedata.com/resource/pubmed/id/12655158
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-3-25
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| pubmed:abstractText |
The aim of this retrospective study was to assess whether intravenous nicorandil, a hybrid of NO and a KATP channel opener, in conjunction with percutaneous coronary intervention (PCI) improves the long-term prognosis in patients with acute myocardial infarction (AMI). Intravenous nicorandil has already been shown to improve the in-hospital prognosis of patients with anterior AMI. The study population consisted of 272 patients with a reperfused AMI who were admitted during a similar time interval, before (control; n=114) and after nicorandil treatment (n=158). In the nicorandil group, a 4 mg bolus injection was given, followed by 6 mg/h infusion for 24 h and then oral nicorandil at 15 mg/day for at least 1 month. In the patients with an anterior AMI, left ventricular (LV) function was better and the frequency of LV remodeling was lower after 3 months in the nicorandil group; however, in those with a non-anterior AMI, there were no differences in functional outcome and the frequency of LV remodeling between the 2 groups. The frequency of cardiac events was significantly lower in the nicorandil group, and the use of nicorandil was derived as a potential factor related to freedom from cardiac events (p<0.01, odds ratio = 0.27). Nicorandil treatment was associated with better myocardial perfusion and a better functional and clinical outcome than PCI alone, and this beneficial effect was maintained for a long time, particularly in patients with anterior AMI.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1346-9843
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| pubmed:author |
pubmed-author:FujiiKenshiK,
pubmed-author:IkushimaMasashiM,
pubmed-author:ItoHiroshiH,
pubmed-author:IwakuraKatsuomiK,
pubmed-author:KatoAkinobuA,
pubmed-author:KawanoShigeoS,
pubmed-author:KimuraRyusukeR,
pubmed-author:MasuyamaTohruT,
pubmed-author:OgiharaToshioT,
pubmed-author:SugimotoKenK,
pubmed-author:TanakaKojiK
|
| pubmed:issnType |
Print
|
| pubmed:volume |
67
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
295-300
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12655158-Aged,
pubmed-meshheading:12655158-Angioplasty, Balloon, Coronary,
pubmed-meshheading:12655158-Case-Control Studies,
pubmed-meshheading:12655158-Echocardiography,
pubmed-meshheading:12655158-Female,
pubmed-meshheading:12655158-Humans,
pubmed-meshheading:12655158-Male,
pubmed-meshheading:12655158-Microcirculation,
pubmed-meshheading:12655158-Middle Aged,
pubmed-meshheading:12655158-Myocardial Infarction,
pubmed-meshheading:12655158-Nicorandil,
pubmed-meshheading:12655158-Prognosis,
pubmed-meshheading:12655158-Retrospective Studies,
pubmed-meshheading:12655158-Time Factors,
pubmed-meshheading:12655158-Vasodilator Agents,
pubmed-meshheading:12655158-Ventricular Function, Left,
pubmed-meshheading:12655158-Ventricular Remodeling
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction.
|
| pubmed:affiliation |
Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan.
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| pubmed:publicationType |
Journal Article
|