Linked Life Data

12653845

Source:http://linkedlifedata.com/resource/pubmed/id/12653845

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-3-25
pubmed:abstractText
Intestinal parasitic infections have been suggested to cause persistent immune activation leading to an unbalanced immune state. Such a state has been proposed to be a major factor in the pathogenesis of AIDS in an African context. The present study investigated the effect of incidental parasitic infection and treatment on the profile of T cell differentiation and activation markers on CD4+ and CD8+ T cells from HIV-1 infected and uninfected adult Ethiopians. Cryopreserved PBMCs from 64 subjects (41 HIV-negative and 23 HIV-positive) with follow-up visits at 6-monthly intervals were used to compare the effect of incidental intestinal parasites and their treatment upon T cell subset profiles and activation status. The samples were stained with antibodies to various T cell differentiation and activation markers allowing naive, memory, effector, memory/effector, activated and resting CD4+ and CD8+ T cell subsets to be quantified by triple-colour FACScan. Incidental intestinal parasitic infections resulted in a significant increase in memory CD4+ T cell numbers both in HIV-negative and HIV-positive subjects (P < 0.05). There was also a significant increase in the percentage of CD8+ HLA-DR+ T cells (P < 0.05) in HIV-positive subjects co-infected with parasites. In HIV-negative subjects, a significant decline in activated cells and a significant increase in resting CD8+ T cells (P < 0.05) was observed after treatment for parasites. These data suggest that intestinal parasitic infections could result in the alteration of T cell subset counts and also in the up-regulation of T cell activation markers in peripheral blood. Treatment of parasitic infections showed a tendency to reduce the activation suggesting that, together with other community based intervention strategies, such treatment could be used to down-regulate immune activation and hence protect the host from being easily attacked by HIV.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10193416, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10203715, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10225845, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10416532, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10449282, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10529774, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10551734, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10827869, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-10884872, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-11032865, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-11207651, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-11687459, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-13762174, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-15275146, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-2117270, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-2510291, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-3309940, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-7689607, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-7734046, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-7907956, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-7930717, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-7995936, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8105270, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8225573, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8235617, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8413664, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8454874, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8493571, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8565306, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8647218, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-8810254, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9030867, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9120023, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9207006, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9416363, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9416366, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9463685, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9472654, http://linkedlifedata.com/resource/pubmed/commentcorrection/12653845-9844052
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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