Source:http://linkedlifedata.com/resource/pubmed/id/12649184
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2003-3-21
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| pubmed:abstractText |
Folate metabolism is thought to play an important role in carcinogenesis through its involvement in both DNA methylation and nucleotide synthesis. A common Ala(222)/Val variant in the methylenetetrahydrofolate reductase (MTHFR) gene leads to a disturbed folate metabolism and is associated with decreased genomic DNA methylation. We previously reported that the MTHFR Val/Val genotype was associated with increased cancer mortality in men from a population-based cohort of subjects ages > or = 85 years. To further explore the deleterious effects of the MTHFR genotype, we studied the association of the genotype with cancer risk in 860 men ages 65-84 years who were followed >10 years (Zutphen Elderly Study). During follow-up, 149 new cases of cancer occurred among the 793 men without cancer at baseline. The risk of developing cancer was 1.80-fold (95% confidence interval, 1.09-3.00) higher among men with the Val/Val genotype than among men with the Ala/Ala genotype. Except for lung cancer [relative risk (RR), 1.15], the risks of common forms of cancers were significantly increased among men with the Val/Val genotype [cancer of the prostate (RR, 3.48); the colorectum (RR, 3.65); the kidney and bladder (RR, 5.48)]. The risks of cancer were particularly increased among men with a lower folate and a higher alcohol intake and men of an older age. In conclusion, our current and previous studies in two independent populations indicate that a common Ala/Val variant in the MTHFR gene is a risk factor for cancer in elderly men from the general population. The mechanism underlying this association might involve genomic instability as a result of insufficient methylation of genomic DNA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0008-5472
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
63
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1249-53
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12649184-Aged,
pubmed-meshheading:12649184-Aged, 80 and over,
pubmed-meshheading:12649184-Alcohol Drinking,
pubmed-meshheading:12649184-Chromosomes, Human, Pair 1,
pubmed-meshheading:12649184-Cohort Studies,
pubmed-meshheading:12649184-Diet,
pubmed-meshheading:12649184-Folic Acid,
pubmed-meshheading:12649184-Genetic Predisposition to Disease,
pubmed-meshheading:12649184-Genetic Variation,
pubmed-meshheading:12649184-Genotype,
pubmed-meshheading:12649184-Humans,
pubmed-meshheading:12649184-Longitudinal Studies,
pubmed-meshheading:12649184-Male,
pubmed-meshheading:12649184-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:12649184-Neoplasms,
pubmed-meshheading:12649184-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:12649184-Prospective Studies,
pubmed-meshheading:12649184-Smoking
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.
|
| pubmed:affiliation |
Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, 2300 RA Leiden, the Netherlands. b.t.heijmans@lumnc.nl
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|