Linked Life Data

12644912

Source:http://linkedlifedata.com/resource/pubmed/id/12644912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-3-19
pubmed:abstractText
Connections between cells are achieved by proteins called connexins that comprise the gap junction. Connexins play a major role in organ development. Our reverse transcription-polymerase chain reaction (RT-PCR) studies demonstrate that Cx30, Cx36, Cx37, Cx40, Cx45, Cx46, and Cx50 are expressed in the kidney. Quantitative RT-PCR indicates that Cx37, Cx45, and Cx46 are preferentially expressed during early renal development. We also explored the expression of connexins in neonatal unilateral ureteral obstruction (UUO). After 12 days of neonatal UUO, the renal mRNA expression of Cx30, Cx37, and Cx40 was significantly elevated. In contrast, there was no change in connexin renal mRNA levels in adult UUO. We conclude that multiple connexins are expressed in the rat kidney and several are aberrantly expressed in neonatal UUO.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-24
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Expression of connexins in the normal and obstructed developing kidney.
pubmed:affiliation
Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. dsilve@lsuhsc.edu
pubmed:publicationType
Journal Article