| pubmed-article:12642497 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12642497 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:12642497 | lifeskim:mentions | umls-concept:C1336596 | lld:lifeskim |
| pubmed-article:12642497 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:12642497 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12642497 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12642497 | pubmed:dateCreated | 2003-3-18 | lld:pubmed |
| pubmed-article:12642497 | pubmed:abstractText | Caudalizing factors operate in the context of Wnt/beta-catenin signaling to induce gene expression in discrete compartments along the rostral-caudal axis of the developing vertebrate nervous system. In zebrafish, basal repression of caudal genes is achieved through the function of Headless (Hdl), a Tcf3 homolog. In this study, we show that a second Tcf3 homolog, Tcf3b, limits caudalization caused by loss of Hdl function and although this Lef/Tcf family member can rescue hdl mutants, Lef1 cannot. Wnts can antagonize repression mediated by Tcf3 and this derepression is dependent on a Tcf3 beta-catenin binding domain. Systematic changes in gene expression caused by reduced Tcf3 function help predict the shape of a caudalizing activity gradient that defines compartments along the rostral-caudal axis. In addition, Tcf3b has a second and unique role in the morphogenesis of rhombomere boundaries, indicating that it controls multiple aspects of brain development. | lld:pubmed |
| pubmed-article:12642497 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12642497 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12642497 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12642497 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12642497 | pubmed:month | May | lld:pubmed |
| pubmed-article:12642497 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:12642497 | pubmed:author | pubmed-author:MoonRandall... | lld:pubmed |
| pubmed-article:12642497 | pubmed:author | pubmed-author:DorskyRichard... | lld:pubmed |
| pubmed-article:12642497 | pubmed:author | pubmed-author:ItohMotoyukiM | lld:pubmed |
| pubmed-article:12642497 | pubmed:author | pubmed-author:ChitnisAjayA | lld:pubmed |
| pubmed-article:12642497 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12642497 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:12642497 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12642497 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12642497 | pubmed:pagination | 1937-47 | lld:pubmed |
| pubmed-article:12642497 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12642497 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12642497 | pubmed:articleTitle | Two tcf3 genes cooperate to pattern the zebrafish brain. | lld:pubmed |
| pubmed-article:12642497 | pubmed:affiliation | Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA. richard.dorsky@hsc.utah.edu | lld:pubmed |
| pubmed-article:12642497 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12642497 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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