Linked Life Data

12618124

Source:http://linkedlifedata.com/resource/pubmed/id/12618124

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-3-5
pubmed:abstractText
One of the hypotheses regarding the pathogenesis of familial ALS (FALS) is a copper-mediated oxidative toxicity derived from the mutant Cu, Zn-superoxide dismutase (SOD1). We have previously demonstrated the efficacy of the combined treatment with a copper chelator (trientine) and an antioxidant (ascorbate) on the disease expression of the FALS-linked mutated SOD1 transgenic mice. Here, we investigated the efficacy of trientine or ascorbate alone on FALS mice when administered before or after the onset of the disease. The mice with a high dose of trientine or ascorbate administered before the onset survived significantly longer than the control. In the combined treatment with a high dose of trientine and ascorbate initiated before the onset, survival lengthened and the motor function of the mice remained more significantly than the control. None of the treatments affected the mean age of the onset, and none of the agents administered after the onset prolonged survival. These findings suggest that better outcomes may be expected by the administration of these agents at the preonset stage of the disease, and the combination of the agents acting on different sites might be useful in preserving the motor performance in FALS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-80
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:12618124-Amyotrophic Lateral Sclerosis, pubmed-meshheading:12618124-Animals, pubmed-meshheading:12618124-Antioxidants, pubmed-meshheading:12618124-Ascorbic Acid, pubmed-meshheading:12618124-Chelating Agents, pubmed-meshheading:12618124-Disease Models, Animal, pubmed-meshheading:12618124-Disease Progression, pubmed-meshheading:12618124-Dose-Response Relationship, Drug, pubmed-meshheading:12618124-Drug Evaluation, Preclinical, pubmed-meshheading:12618124-Drug Therapy, Combination, pubmed-meshheading:12618124-Humans, pubmed-meshheading:12618124-Male, pubmed-meshheading:12618124-Mice, pubmed-meshheading:12618124-Mice, Transgenic, pubmed-meshheading:12618124-Superoxide Dismutase, pubmed-meshheading:12618124-Survival Rate, pubmed-meshheading:12618124-Treatment Outcome, pubmed-meshheading:12618124-Trientine
pubmed:year
2003
pubmed:articleTitle
The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice.
pubmed:affiliation
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
pubmed:publicationType
Journal Article, Comparative Study