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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-27
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pubmed:abstractText |
The molecular properties that characterize CD4+CD25+ regulatory T cells (TR cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and encoded by Foxp3) causes a rapidly fatal lymphoproliferative disease, similar to that seen in mice lacking cytolytic T lymphocyte-associated antigen 4 (CTLA-4). Here we show that Foxp3 is highly expressed by T(R) cells and is associated with T(R) cell activity and phenotype. Scurfin-deficient mice lack T(R) cells, whereas mice that overexpress Foxp3 possess more T(R) cells. In Foxp3-overexpressing mice, both CD4+CD25- and CD4-CD8+ T cells show suppressive activity and CD4+CD25- cells express glucocorticoid-induced tumor-necrosis factor receptor-related (GITR) protein. The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoid-Induced...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF18 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf18 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-42
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12612581-Animals,
pubmed-meshheading:12612581-Antigens, CD,
pubmed-meshheading:12612581-Antigens, Differentiation,
pubmed-meshheading:12612581-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12612581-CTLA-4 Antigen,
pubmed-meshheading:12612581-DNA-Binding Proteins,
pubmed-meshheading:12612581-Forkhead Transcription Factors,
pubmed-meshheading:12612581-Glucocorticoid-Induced TNFR-Related Protein,
pubmed-meshheading:12612581-Immunoconjugates,
pubmed-meshheading:12612581-Interleukin-10,
pubmed-meshheading:12612581-Mice,
pubmed-meshheading:12612581-Mice, Transgenic,
pubmed-meshheading:12612581-Receptors, Interleukin-2,
pubmed-meshheading:12612581-Receptors, Nerve Growth Factor,
pubmed-meshheading:12612581-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12612581-Transforming Growth Factor beta
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pubmed:year |
2003
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pubmed:articleTitle |
An essential role for Scurfin in CD4+CD25+ T regulatory cells.
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pubmed:affiliation |
Celltech R&D Inc., 1631 220th Street SE, Bothell, Washington 98021, USA.
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pubmed:publicationType |
Journal Article
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