| pubmed-article:12606515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0151686 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0694756 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C0167117 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12606515 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:12606515 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12606515 | pubmed:dateCreated | 2003-2-27 | lld:pubmed |
| pubmed-article:12606515 | pubmed:abstractText | Uteroplacental insufficiency resulting in fetal growth retardation is a common complication of pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological studies show an increased incidence of type 2 diabetes in humans who were growth retarded at birth. The mechanisms by which an abnormal intrauterine milieu leads to the development of diabetes in adulthood are not known. Therefore, a rat model of uteroplacental insufficiency was developed; intrauterine growth-retarded (IUGR) rats develop diabetes with a phenotype similar to that observed in the human with type 2 diabetes. We show here that administration of a pancreatic beta-cell trophic factor, exendin-4 (Ex-4), during the prediabetic neonatal period dramatically prevents the development of diabetes in this model. This occurs because neonatal Ex-4 prevents the progressive reduction in insulin-producing beta-cell mass that is observed in IUGR rats over time. Expression of PDX, a critical regulator of pancreas development and islet differentiation, is restored to normal levels, and islet beta-cell proliferation rates are normalized by the neonatal Ex-4 treatment. These results indicate that exposure to Ex-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of diabetes in adulthood. | lld:pubmed |
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| pubmed-article:12606515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12606515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12606515 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12606515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12606515 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12606515 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:12606515 | pubmed:author | pubmed-author:SimmonsRebecc... | lld:pubmed |
| pubmed-article:12606515 | pubmed:author | pubmed-author:StoffersDoris... | lld:pubmed |
| pubmed-article:12606515 | pubmed:author | pubmed-author:DesaiBiva MBM | lld:pubmed |
| pubmed-article:12606515 | pubmed:author | pubmed-author:DeLeonDiva... | lld:pubmed |
| pubmed-article:12606515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12606515 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:12606515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12606515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12606515 | pubmed:pagination | 734-40 | lld:pubmed |
| pubmed-article:12606515 | pubmed:dateRevised | 2011-6-1 | lld:pubmed |
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| pubmed-article:12606515 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12606515 | pubmed:articleTitle | Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. | lld:pubmed |
| pubmed-article:12606515 | pubmed:affiliation | Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Clinical Research Building 611B, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA. stoffers@mail.med.upenn.edu | lld:pubmed |
| pubmed-article:12606515 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12606515 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12606515 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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