|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
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|
pubmed:dateCreated |
2003-4-28
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|
pubmed:abstractText |
Recombinant HIV-1 reverse transcriptase (RT) carrying non-nucleoside inhibitors (NNRTIs) resistance mutation at codon 181 showed reduced incorporation and high efficiency of phosphorolytic removal of stavudine, a nucleoside RT inhibitor. These results reveal a new mechanism for cross-resistance between different classes of HIV-1 RT inhibitors.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
278
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
15469-72
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|
pubmed:dateRevised |
2007-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:12601008-Codon,
pubmed-meshheading:12601008-Drug Resistance, Viral,
pubmed-meshheading:12601008-HIV Reverse Transcriptase,
pubmed-meshheading:12601008-Mutation,
pubmed-meshheading:12601008-Nevirapine,
pubmed-meshheading:12601008-Nucleotides,
pubmed-meshheading:12601008-Phosphorylation,
pubmed-meshheading:12601008-Reverse Transcriptase Inhibitors,
pubmed-meshheading:12601008-Stavudine,
pubmed-meshheading:12601008-Zidovudine
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.
|
|
pubmed:affiliation |
Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, I-27100 Pavia, Italy.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
