| pubmed-article:12586069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12586069 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:12586069 | lifeskim:mentions | umls-concept:C0333051 | lld:lifeskim |
| pubmed-article:12586069 | lifeskim:mentions | umls-concept:C1155342 | lld:lifeskim |
| pubmed-article:12586069 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:12586069 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12586069 | pubmed:dateCreated | 2003-2-14 | lld:pubmed |
| pubmed-article:12586069 | pubmed:abstractText | Unfolded or misfolded proteins in the endoplasmic reticulum (ER) must be refolded or degraded to maintain homeostasis of the ER. The ATF6 and IRE1-XBP1 pathways are important for the refolding process in mammalian cells; activation of these transcriptional programs culminates in induction of ER-localized molecular chaperones and folding enzymes. We show here that degradation of misfolded glycoprotein substrates requires transcriptional induction of EDEM (ER degradation-enhancing alpha-mannosidase-like protein), and that this is mediated specifically by IRE1-XBP1 and not by ATF6. As XBP1 is produced after ATF6 activation, our results reveal a time-dependent transition in the mammalian unfolded protein response: an ATF6-mediated unidirectional phase (refolding only) is followed by an XBP1-mediated bidirectional phase (refolding plus degradation) as the response progresses. | lld:pubmed |
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| pubmed-article:12586069 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12586069 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12586069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12586069 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12586069 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:12586069 | pubmed:author | pubmed-author:KaufmanRandal... | lld:pubmed |
| pubmed-article:12586069 | pubmed:author | pubmed-author:NagataKazuhir... | lld:pubmed |
| pubmed-article:12586069 | pubmed:author | pubmed-author:MoriKazutoshi... | lld:pubmed |
| pubmed-article:12586069 | pubmed:author | pubmed-author:YoshidaHidero... | lld:pubmed |
| pubmed-article:12586069 | pubmed:author | pubmed-author:HosokawaNobuk... | lld:pubmed |
| pubmed-article:12586069 | pubmed:author | pubmed-author:MatsuiToshieT | lld:pubmed |
| pubmed-article:12586069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12586069 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12586069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12586069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12586069 | pubmed:pagination | 265-71 | lld:pubmed |
| pubmed-article:12586069 | pubmed:dateRevised | 2008-9-5 | lld:pubmed |
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| pubmed-article:12586069 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12586069 | pubmed:articleTitle | A time-dependent phase shift in the mammalian unfolded protein response. | lld:pubmed |
| pubmed-article:12586069 | pubmed:affiliation | Graduate School of Biostudies, Kyoto University, Kyoto 606-8304, Japan. | lld:pubmed |
| pubmed-article:12586069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12586069 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12586069 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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