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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1976-6-2
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pubmed:abstractText |
The local effect of intra-arterial infusion of amitriptyline (AT) on forearm blood flow was studied in seven healthy subjects. AT was infused at rates of 0.05, 0.10, 0.15, and 0.20 mg-min--1 for periods of 5 min. Forearm blood flow showed a dose-dependent increase when the dose exeeded 0.10 mg-min--1. On the highest dose level the blood flow increased on an average by 73%. No systemic effects, as reflected by changes in heart rate, blood pressure, and blood flow in the contralateral forearm, were observed during the infusion. The present data indicate a dilatating effect of AT on resistance vessels possibly mediated by an alpha-adrenergic blockade.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-5513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-21
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1257692-Adult,
pubmed-meshheading:1257692-Amitriptyline,
pubmed-meshheading:1257692-Blood Circulation,
pubmed-meshheading:1257692-Blood Pressure,
pubmed-meshheading:1257692-Forearm,
pubmed-meshheading:1257692-Heart Rate,
pubmed-meshheading:1257692-Humans,
pubmed-meshheading:1257692-Injections, Intra-Arterial,
pubmed-meshheading:1257692-Male,
pubmed-meshheading:1257692-Middle Aged,
pubmed-meshheading:1257692-Vascular Resistance
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pubmed:year |
1976
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pubmed:articleTitle |
The effect of amitriptyline on forearm blood flow.
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pubmed:publicationType |
Journal Article
|