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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-30
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pubmed:abstractText |
Reports suggest that a subset of uveal melanoma is familial. The association of uveal melanoma with breast and ovarian cancer and the increased risk in BRCA2-linked families implicates germline BRCA2 mutations as the cause of a subset of uveal melanomas. Similarly, the association between cutaneous and uveal melanomas in some families, coupled with the high frequency of somatic deletions of the INK4A-ARF locus in uveal melanomas, strongly suggests that mutations in P16(INK4A) and P15 account for a proportion of uveal melanomas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BRCA2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN2B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p14ARF,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
458-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12556369-Adult,
pubmed-meshheading:12556369-Aged,
pubmed-meshheading:12556369-Aged, 80 and over,
pubmed-meshheading:12556369-BRCA2 Protein,
pubmed-meshheading:12556369-Cell Cycle Proteins,
pubmed-meshheading:12556369-Cyclin-Dependent Kinase Inhibitor p15,
pubmed-meshheading:12556369-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:12556369-DNA, Neoplasm,
pubmed-meshheading:12556369-DNA Mutational Analysis,
pubmed-meshheading:12556369-Female,
pubmed-meshheading:12556369-Germ-Line Mutation,
pubmed-meshheading:12556369-Humans,
pubmed-meshheading:12556369-Incidence,
pubmed-meshheading:12556369-Male,
pubmed-meshheading:12556369-Melanoma,
pubmed-meshheading:12556369-Middle Aged,
pubmed-meshheading:12556369-Polymerase Chain Reaction,
pubmed-meshheading:12556369-Transcription Factors,
pubmed-meshheading:12556369-Tumor Suppressor Protein p14ARF,
pubmed-meshheading:12556369-Tumor Suppressor Proteins,
pubmed-meshheading:12556369-Uveal Neoplasms
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pubmed:year |
2003
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pubmed:articleTitle |
Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma.
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pubmed:affiliation |
Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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