Linked Life Data

12555153

Source:http://linkedlifedata.com/resource/pubmed/id/12555153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Suppl
pubmed:dateCreated
2003-1-29
pubmed:abstractText
Cardiac myocytes respond to biomechanical stress by initiating cellular processes that lead to hypertrophy. Although cardiac hypertrophy is a response to increased stress on the heart, it is also associated with elevated plasma catecholamine levels and an increase in cardiac morbidity and mortality. Understanding the cellular signals that initiate the hypertrophic response is of critical importance in identifying pathways that mediate the hypertrophic heart's maladaptive deterioration to cardiac failure. Here we present data demonstrating an important role for G protein-coupled receptors in the induction of in vivo cardiac hypertrophy and the activation of signaling pathways, such as the mitogen activated protein kinase and phosphoinositide-3 kinase pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1071-9164
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S409-14
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Cardiac hypertrophy: role of G protein-coupled receptors.
pubmed:affiliation
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
pubmed:publicationType
Journal Article