Source:http://linkedlifedata.com/resource/pubmed/id/12545089
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-1-24
|
| pubmed:abstractText |
Increased drug levels could overcome resistance and improve the response to a salvage regimen. We evaluate the inhibitory quotient (IQ, Ctrough/protein-binding corrected IC50) as a predictor of virological response in 52 patients included in two dual protease inhibitor (PI)-based salvage regimens. The HIV-RNA level decrease at 12 weeks was greater in patients who achieved an IQ greater than 1. The IQ could be useful to improve the virological response to a dual PI salvage regimen.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0269-9370
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
262-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12545089-Drug Resistance, Viral,
pubmed-meshheading:12545089-Drug Therapy, Combination,
pubmed-meshheading:12545089-HIV Infections,
pubmed-meshheading:12545089-HIV Protease Inhibitors,
pubmed-meshheading:12545089-HIV-1,
pubmed-meshheading:12545089-Humans,
pubmed-meshheading:12545089-Salvage Therapy
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Individualizing salvage regimens: the inhibitory quotient (Ctrough/IC50) as predictor of virological response.
|
| pubmed:affiliation |
Department of Infectious Diseases, Ramon y Cajal Hospital, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|