Source:http://linkedlifedata.com/resource/pubmed/id/12535263
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
2003-1-21
|
pubmed:abstractText |
A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1398-2273
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
201-6
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:12535263-Adult,
pubmed-meshheading:12535263-Antiviral Agents,
pubmed-meshheading:12535263-Bone Marrow Transplantation,
pubmed-meshheading:12535263-Cytomegalovirus,
pubmed-meshheading:12535263-Cytomegalovirus Infections,
pubmed-meshheading:12535263-Drug Resistance, Viral,
pubmed-meshheading:12535263-Encephalitis, Viral,
pubmed-meshheading:12535263-Foscarnet,
pubmed-meshheading:12535263-Ganciclovir,
pubmed-meshheading:12535263-Humans,
pubmed-meshheading:12535263-Leukodystrophy, Metachromatic,
pubmed-meshheading:12535263-Male
|
pubmed:year |
2002
|
pubmed:articleTitle |
Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient.
|
pubmed:affiliation |
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
|