| pubmed-article:12526084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12526084 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:12526084 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12526084 | lifeskim:mentions | umls-concept:C1419771 | lld:lifeskim |
| pubmed-article:12526084 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12526084 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12526084 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12526084 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12526084 | pubmed:dateCreated | 2003-1-14 | lld:pubmed |
| pubmed-article:12526084 | pubmed:abstractText | Skeletogenesis occurs through either intramembranous or endochondral ossification. In addition, some parts of the skeletal components maintain their cartilaginous characteristics throughout life without mineralization. Runx2 is known to be a pivotal transcription factor for all skeletogenic processes. In this study, we examined the expression patterns of two major isoforms of Runx2 in early skeletogenesis. During intramembranous bone formation, Runx2-type I (Runx2-I) was widely expressed in osteoprogenitor cells and active osteoblasts, while Runx2-type II (Runx2-II) expression was stringently restricted to cells lining mineralized bones. Cells in permanent cartilage expressed collagen type II (Col-II) but never expressed Runx2 or Col-X. These permanent cartilages were well circumscribed by Runx2-I positive cells, in which Runx2-II was negative. In endochondral bone formation, Runx2 expression temporarily disappeared in Col-II-positive proliferating chondrocytes, but a secondary surge of Runx2-I expression occurred in the prehypertrophic zone before the mineralization of cartilage. Collectively, both Runx2 isoforms showed very similar expression patterns in active bone forming areas; however, Runx2-I has an exclusive role in the early commitment stage of intramembranous or endochondral bone forming processes or in cells surrounding permanent cartilage. | lld:pubmed |
| pubmed-article:12526084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12526084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12526084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12526084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12526084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12526084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12526084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12526084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12526084 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12526084 | pubmed:issn | 1226-3613 | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:BaeYong-ChulY... | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:KimHyun-JungH... | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:LeeSang-WonSW | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:KimYoung-JinY... | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:ShinHong-InHI | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:RyooHyun-MoHM | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:ChoiKang-Youn... | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:ParkMi-HyunMH | lld:pubmed |
| pubmed-article:12526084 | pubmed:author | pubmed-author:NamSoon-... | lld:pubmed |
| pubmed-article:12526084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12526084 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:12526084 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:12526084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12526084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12526084 | pubmed:pagination | 426-33 | lld:pubmed |
| pubmed-article:12526084 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:meshHeading | pubmed-meshheading:12526084... | lld:pubmed |
| pubmed-article:12526084 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12526084 | pubmed:articleTitle | Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis. | lld:pubmed |
| pubmed-article:12526084 | pubmed:affiliation | Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea. | lld:pubmed |
| pubmed-article:12526084 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12526084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12393 | entrezgene:pubmed | pubmed-article:12526084 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12526084 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12526084 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12526084 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12526084 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12526084 | lld:pubmed |
