Linked Life Data

12519448

Source:http://linkedlifedata.com/resource/pubmed/id/12519448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-1-9
pubmed:abstractText
The objective of the present study was to provide a pathophysiological model of the development of schizophrenia. The method used was a selective review of recent findings, including those in our own department, concerning the clinical symptoms, cognitive characteristics and morphological brain changes in schizophrenia. A four-syndrome classification was proposed in which 'alienation syndrome' is separated from delusion syndrome. Memory organization deficit in schizophrenia patients was correlated with reduced activation of the left inferior frontal regions. Magnetic resonance imaging and statistical parametric mapping analysis revealed that volume reduction in the temporal lobe was seen in both schizotypal disorder and schizophrenia patients, but schizophrenia patients had additional changes in the medial and dorsolateral frontal regions. In conclusion, a temporo-frontal dual pathology of schizophrenia was suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1323-1316
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Pathogenesis of schizophrenia: Part I. Symptomatology, cognitive characteristics and brain morphology.
pubmed:affiliation
Department of Psychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan. kurachi@ms.toyama-mpu.ac.jp
pubmed:publicationType
Journal Article, Review