Linked Life Data

12517686

Source:http://linkedlifedata.com/resource/pubmed/id/12517686

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-1-8
pubmed:abstractText
Nicotonic acid (NA) infusions are associated with peripheral vasodilation from the generation of vascular prostaglandins with minimal effects on blood pressure (BP) in normotensive subjects. We studied the effects of a NA infusion in 10 hypertensive and 11 normotensive individuals to further characterize systemic hemodynamic responses to NA using pulse waveform analysis. Blood pressure, stroke volume, cardiac output, total peripheral resistance, large and small artery elasticity were determined before and after a 1-h NA infusion. In the normotensives, systolic, diastolic, mean BP, and pulse pressure were not affected by NA. In contrast, the hypertensive subjects experienced a decrease in mean BP from 105 +/- 2 mm Hg to 100 +/- 3 mm Hg (P <.01) accompanied by significant decreases in systolic, diastolic, and pulse pressures. The differential BP response occurred despite comparable increases in heart rate (11% to 13%, P </=.05) and similar decreases in total peripheral resistance (6%, P </=.05) in both groups. However, the normotensive group demonstrated a decrease in overall vascular compliance, measured as stroke volume to pulse pressure ratio, from 2.12 +/- 0.09 to 1.93 +/- 0.09 mL/mm Hg (P <.05). This finding was supported by a decrease in C1 (large artery compliance), assessed by pulse waveform analysis, from 15.8 +/- 1 to 14.2 +/- 1 mL/mm Hg (P <.05). In contrast, overall compliance and C1 were unchanged after the NA infusion in the hypertensive group. These results suggest that there is a differential hemodynamic response to NA infusion in normotensive and hypertensive individuals. The adjustment in vascular compliance may be an important factor in determining overall BP response to NA.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0895-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-71
pubmed:dateRevised
2009-2-24
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects.
pubmed:affiliation
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. gadegbek@musc.edu
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Controlled Clinical Trial, Research Support, Non-U.S. Gov't