| pubmed-article:12484517 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C0022709 | lld:lifeskim |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C1524081 | lld:lifeskim |
| pubmed-article:12484517 | lifeskim:mentions | umls-concept:C0857121 | lld:lifeskim |
| pubmed-article:12484517 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12484517 | pubmed:dateCreated | 2002-12-17 | lld:pubmed |
| pubmed-article:12484517 | pubmed:abstractText | The aim of this study was to evaluate the effects of moderate-intensity regular exercise and/or an angiotensin converting enzyme (ACE) inhibition on tumor necrosis factor-alpha (TNF-alpha) and glucose and lipid metabolism parameters. Spontaneously hypertensive rats (SHRs) were fed a fructose-rich diet during 16 weeks of either exercise training (Ex group: 20 m/min, 0% grade, 60 min/day, 5 days/week), administration of an ACE inhibitor (TM group: temocapril, 10 mg/kg/day), or a combination of both (TM+Ex group). The systolic blood pressure was reduced exclusively in the TM and TM+Ex group. Epididymal fat pads (EPI) weighed less in the TM+Ex group than in the single-treatment (TM) group. The serum leptin level was significantly and directly correlated with the EPI weight (p < 0.001). The TNF-alpha content per gram of EPI was the highest in the TM+Ex group. In addition, the EPI TNF-alpha level was negatively correlated with both the EPI weight and the serum leptin level (p < 0.001, respectively). In contrast, the TNF-alpha level of skeletal muscles was identical among the groups. The extensor digitorum longus had a significantly higher abundance of TNF-alpha protein than the soleus muscle. These data indicate that the local TNF-alpha expression is tissue-specific, and that upregulation of TNF-alpha in EPI by exercise training and/or ACE inhibition may have contributed to the reduction in fat cell volume via the induction of apoptosis and/or the regulation of metabolic homeostasis. | lld:pubmed |
| pubmed-article:12484517 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12484517 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12484517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12484517 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12484517 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12484517 | pubmed:issn | 0916-9636 | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:TakeuchiKazuh... | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:SugawaraAkira... | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:KohzukiMasahi... | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:YoshidaKazuno... | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:KawamuraTakay... | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:MoriNobuyoshi... | lld:pubmed |
| pubmed-article:12484517 | pubmed:author | pubmed-author:NagasakaMakot... | lld:pubmed |
| pubmed-article:12484517 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12484517 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:12484517 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12484517 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12484517 | pubmed:pagination | 919-26 | lld:pubmed |
| pubmed-article:12484517 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:meshHeading | pubmed-meshheading:12484517... | lld:pubmed |
| pubmed-article:12484517 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12484517 | pubmed:articleTitle | Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats. | lld:pubmed |
| pubmed-article:12484517 | pubmed:affiliation | Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan. | lld:pubmed |
| pubmed-article:12484517 | pubmed:publicationType | Journal Article | lld:pubmed |
