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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-6
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pubmed:abstractText |
A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmacokinetic model to assess plasma levels at 1mg/kg (po) and in the rat situational anxiety model to assess anxiolytic efficacy at 3mg/kg (po). The structure-activity relationships for good receptor binding affinity are described herein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ArnericStephen PSP,
pubmed-author:ArnoldCharles RCR,
pubmed-author:ArvanitisArgyrios GAG,
pubmed-author:CainGary AGA,
pubmed-author:FitzgeraldLawrence WLW,
pubmed-author:GilliganPaul JPJ,
pubmed-author:GrossmanScottS,
pubmed-author:HartigPaul RPR,
pubmed-author:McElroyJohnJ,
pubmed-author:OlsonRichard ERE,
pubmed-author:RescinitoJoseph TJT,
pubmed-author:RobertsonDavid WDW,
pubmed-author:SunJung HuiJH,
pubmed-author:TelehaChristopher ACA,
pubmed-author:WildeRichard GRG,
pubmed-author:YanJia-ShengJS,
pubmed-author:ZaczekRobertR
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:12467631-Animals,
pubmed-meshheading:12467631-Anti-Anxiety Agents,
pubmed-meshheading:12467631-Anxiety Disorders,
pubmed-meshheading:12467631-Dogs,
pubmed-meshheading:12467631-Half-Life,
pubmed-meshheading:12467631-Ligands,
pubmed-meshheading:12467631-Metabolic Clearance Rate,
pubmed-meshheading:12467631-Pyridines,
pubmed-meshheading:12467631-Rats,
pubmed-meshheading:12467631-Receptors, Corticotropin-Releasing Hormone,
pubmed-meshheading:12467631-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands.
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pubmed:affiliation |
Discovery Chemistry-Wilmington, Bristol-Myers Squibb Company, Experimental Station, DE 19880, USA. argyrios.arvanitis@bms.com
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pubmed:publicationType |
Journal Article
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