| pubmed-article:12428723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C0037369 | lld:lifeskim |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C0036866 | lld:lifeskim |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C0021920 | lld:lifeskim |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:12428723 | lifeskim:mentions | umls-concept:C0026456 | lld:lifeskim |
| pubmed-article:12428723 | pubmed:issue | 4-5 | lld:pubmed |
| pubmed-article:12428723 | pubmed:dateCreated | 2002-11-13 | lld:pubmed |
| pubmed-article:12428723 | pubmed:abstractText | We tested for gender-specific interactions between smoking and genetic polymorphisms of monoamine oxidase B (MAO-B) intron 13 (G or A allele), monoamine oxidase A (MAO-A) EcoRV (Yor N allele), and dopamine D2 recepor (DRD2) Taq1B (B1 or B2 allele) in a case-control study of 186 incident idiopathic Parkinson's disease (PD) cases and 296 age- and gender-matched controls. The odds ratios (ORs) for PD risk for ever smokers versus never smokers were 0.27 (95% CI: 0.13-0.58) for men of genotype G, and 1.26 (0.60-2.63) for men of genotype A (interaction chi2 = 8.14, P = 0.004). In contrast, for women, the OR for ever smokers versus never smokers were 0.62 (95% CI: 0.25-1.34) and 0.64 (95% CI: 0.18-2.21) for women of genotype GG/GA and AA, respectively (interaction chi2 = 0.001, P = 0.975). No interactions were detected between smoking and either MAO-A EcoRV or DRD2 Taq1B genotypes. These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD. | lld:pubmed |
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| pubmed-article:12428723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12428723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12428723 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12428723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12428723 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12428723 | pubmed:issn | 0161-813X | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:LongstrethW... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:CostaLucio... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:CheckowayHarv... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:FranklinGary... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:SwansonPhilli... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:KeladaSamir... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:Costa-MallenP... | lld:pubmed |
| pubmed-article:12428723 | pubmed:author | pubmed-author:Smith-WellerT... | lld:pubmed |
| pubmed-article:12428723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12428723 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12428723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12428723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12428723 | pubmed:pagination | 515-9 | lld:pubmed |
| pubmed-article:12428723 | pubmed:dateRevised | 2008-8-29 | lld:pubmed |
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| pubmed-article:12428723 | pubmed:meshHeading | pubmed-meshheading:12428723... | lld:pubmed |
| pubmed-article:12428723 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12428723 | pubmed:articleTitle | Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease. | lld:pubmed |
| pubmed-article:12428723 | pubmed:affiliation | Department of Environmental Health, University of Washington, Seattle 98195, USA. skelada@u.washington.edu | lld:pubmed |
| pubmed-article:12428723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12428723 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12428723 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12428723 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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