Linked Life Data

12428274

Source:http://linkedlifedata.com/resource/pubmed/id/12428274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-11-13
pubmed:abstractText
Effects of idiotypic and antiidiotypic antibodies against protein S100b on synaptic transmission and long-term potentiation of CA1 pyramidal neurons in rat hippocampus were studied. Idiotypic antibodies against protein S100b inhibited synaptic transmission from Schaffer collateral axons to pyramidal neurons, but had no effect on neuronal responses to antidromic stimulation. Antiidiotypic antibodies against protein S100b facilitated neuronal responses to orthodromic stimulation. Idiotypic antibodies against protein S100b suppressed changes in neuronal responses to orthodromic stimulation during long-term potentiation, while antiidiotypic antibodies facilitated these effects. Our findings suggest that the effects of idiotypic and antiidiotypic antibodies to protein S100b are associated with their regulatory influences on synaptic transmission. These mechanisms differ from mechanisms of synaptic plasticity involved in long-term potentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-4888
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Effects of antibodies against protein S100b on synaptic transmission and long-term potentiation in CA-1 hippocampal neurons in rats.
pubmed:affiliation
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't