| pubmed-article:12424341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0043342 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0007301 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0596392 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0013574 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0205618 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0100748 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:12424341 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12424341 | pubmed:dateCreated | 2002-11-27 | lld:pubmed |
| pubmed-article:12424341 | pubmed:abstractText | Activin A has potent mesoderm-inducing activity in amphibian embryos and induces various mesodermal tissues in vitro from the isolated presumptive ectoderm. By using a sandwich culture method established to examine activin A activity, we previously demonstrated that activin-treated ectoderm can function as both a head and trunk-tail organizer, depending on the concentration of activin A. By using activin A and undifferentiated presumptive ectoderm, it is theoretically possible to reproduce embryonic induction. Here, we test this hypothesis by studying the induction of cartilage tissue by using the sandwich-culture method. In the sandwiched explants, the mesenchymal cell condensation expressed type II collagen and cartilage homeoprotein-1 mRNA, and subsequently, cartilage were induced as they are in vivo. goosecoid (gsc) mRNA was prominently expressed in the cartilage in the explants. Xenopus distal-less 4 (X-dll4) mRNA was expressed throughout the explants. In Xenopus embryos, gsc expression is restricted to the cartilage of the lower jaw, and X-dll4 is widely expressed in the ventral head region, including craniofacial cartilage. These finding suggest that the craniofacial cartilage, especially lower jaw cartilage, was induced in the activin-treated sandwiched explants. In addition, a normal developmental pattern was recapitulated at the histological and genetic level. This work also suggests that the craniofacial cartilage-induction pathway is downstream of activin A. This study presents a model system suitable for the in vitro analysis of craniofacial cartilage induction in vertebrates. | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12424341 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12424341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12424341 | pubmed:author | pubmed-author:AsashimaMakot... | lld:pubmed |
| pubmed-article:12424341 | pubmed:author | pubmed-author:OkamotoTetsuj... | lld:pubmed |
| pubmed-article:12424341 | pubmed:author | pubmed-author:FurueMihoM | lld:pubmed |
| pubmed-article:12424341 | pubmed:author | pubmed-author:MyoishiYasufu... | lld:pubmed |
| pubmed-article:12424341 | pubmed:author | pubmed-author:FukuiYasutoY | lld:pubmed |
| pubmed-article:12424341 | pubmed:author | pubmed-author:AriizumiTakas... | lld:pubmed |
| pubmed-article:12424341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12424341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12424341 | pubmed:pagination | 15474-9 | lld:pubmed |
| pubmed-article:12424341 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12424341 | pubmed:articleTitle | Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro. | lld:pubmed |
| pubmed-article:12424341 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, Kanagawa Dental College, Yokosuka 238-8580, Japan. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12424341 | lld:pubmed |
