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| pubmed-article:12414794 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:12414794 | pubmed:dateCreated | 2002-12-23 | lld:pubmed |
| pubmed-article:12414794 | pubmed:abstractText | Epidermal growth factor induction of c-jun expression requires ATF1 and MEF2 sites in the c-jun promoter. We find that activation of the c-jun promoter through the ATF1 site requires phosphorylation of ATF1 at serine 63. A serine 63 to alanine mutation of ATF1 acts to block epidermal growth factor (EGF) induction of a transfected c-jun gene. ATF1 can be phosphorylated by mitogen- and stress-activated protein kinase 1 (MSK1), which is activated by EGF and ERK1/2. Kinase-dead MSK1 mutants blocked EGF induction of a transfected c-jun gene suggesting that MSK1 or a similar family member is required for induced c-jun expression. Use of the MEK1 inhibitor U0126 and dominant negative MEK1 further showed that MSK1 activation and c-jun induction require the ERK pathway. In contrast, a JNK inhibitor blocked EGF induction of c-jun expression but not ATF1 phosphorylation. These results show that the two MAPK pathways, ERK and JNK, are required for EGF-induced c-jun expression and that the ERK pathway acts through downstream phosphorylation of ATF1. | lld:pubmed |
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| pubmed-article:12414794 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12414794 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12414794 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12414794 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12414794 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12414794 | pubmed:author | pubmed-author:PrywesRonR | lld:pubmed |
| pubmed-article:12414794 | pubmed:author | pubmed-author:GuptaPankajP | lld:pubmed |
| pubmed-article:12414794 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12414794 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:12414794 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:12414794 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12414794 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12414794 | pubmed:pagination | 50550-6 | lld:pubmed |
| pubmed-article:12414794 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12414794 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12414794 | pubmed:articleTitle | ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression. | lld:pubmed |
| pubmed-article:12414794 | pubmed:affiliation | Department of Biological Sciences, Columbia University, New York, New York 10027, USA. | lld:pubmed |
| pubmed-article:12414794 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12414794 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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