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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-11-4
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pubmed:abstractText |
Transforming growth factor (TGF)-beta-inducible gene-h3 (betaig-h3) product is a secreted protein that is induced by TGF-beta in several cell types and implicated in various tissue pathologies. The aims of this study were to determine the effect of TGF-beta1 on betaig-h3 expression in cultured astrocytes and to examine whether betaig-h3 is expressed in the brain after traumatic injury. The results showed that betaig-h3 mRNA and protein increased in response to TGF-beta1 in U87 human astrocytoma cells and mouse cortical astrocytes. Treatment with other cytokines, including tumor necrosis factor-alpha and fibroblast growth factor-2, did not enhance the expression of betaig-h3 in astrocytes. betaig-h3 was significantly expressed in reactive astrocytes at the site of a stab wound in the cerebral cortex of adult rats. These results provide an insight into understanding a novel role for betaig-h3 protein in the response of astrocytes to brain injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/betaIG-H3 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12414124-Animals,
pubmed-meshheading:12414124-Astrocytes,
pubmed-meshheading:12414124-Brain Injuries,
pubmed-meshheading:12414124-Dose-Response Relationship, Drug,
pubmed-meshheading:12414124-Extracellular Matrix Proteins,
pubmed-meshheading:12414124-Gene Expression Regulation,
pubmed-meshheading:12414124-Glial Fibrillary Acidic Protein,
pubmed-meshheading:12414124-Gliosis,
pubmed-meshheading:12414124-Humans,
pubmed-meshheading:12414124-Immunohistochemistry,
pubmed-meshheading:12414124-Neoplasm Proteins,
pubmed-meshheading:12414124-RNA, Messenger,
pubmed-meshheading:12414124-Rats,
pubmed-meshheading:12414124-Rats, Sprague-Dawley,
pubmed-meshheading:12414124-Transforming Growth Factor beta,
pubmed-meshheading:12414124-Transforming Growth Factor beta1,
pubmed-meshheading:12414124-Tumor Cells, Cultured,
pubmed-meshheading:12414124-Up-Regulation,
pubmed-meshheading:12414124-Wound Healing
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pubmed:year |
2002
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pubmed:articleTitle |
Induction of TGF-beta-inducible gene-h3 (betaig-h3) by TGF-beta1 in astrocytes: implications for astrocyte response to brain injury.
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pubmed:affiliation |
Graduate School of East-West Medical Science, Kyung Hee University, Yong-In 449-701, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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