Linked Life Data

1239002

Source:http://linkedlifedata.com/resource/pubmed/id/1239002

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-3-1
pubmed:abstractText
1. In cardiac Purkinje fibers the temperature sensitivity of the membrane current flowing after 2 sec in response to depolarizing clamp steps was recorded. When the temperature was quickly lowered (30 sec) from 37 degrees C to 20 degrees C for a period of 2 min the outward current was markedly reduced. The effect was immediately reversed upon rewarming. The reduction in outward current on cooling was most pronounced between 30 degrees C and 20 degrees C. 2. In the range of anomalous rectification cooling to 20 degrees C shifted the i.v. relation in a negative direction by a constant amount of 20 nA. Outside this potential range (negative to -80 mV and positive to -45 mV) the slope conductance was reduced with a Q10 of about 1.3. 3. In the presence of dihydroouabain cooling did not further reduce the outward current in the potential range of anomalous rectification. However, negative to -80 mV and positive to -40 mV the slope conductance was reduced. The results support the view that part of the outward current is generated by an electrogenic sodium pump which is inhibited by cooling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
358
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-34
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Temperature sensitivity of outward current in cardiac Purkinje fibers. Evidence of electrogenicity of active transport.
pubmed:publicationType
Journal Article