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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-9-30
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pubmed:abstractText |
The monoclonal antibody M-DC8 defines a major subset of human blood dendritic cells (DCs). Here we identify the M-DC8 structure as 6-sulfo LacNAc, a novel carbohydrate modification of the P selectin glycoprotein ligand 1 (PSGL-1). In contrast to previously described blood DCs, M-DC8+ DCs lack the cutaneous lymphocyte antigen (CLA) on PSGL-1 and fail to bind P and E selectin. Yet they express anaphylatoxin receptors (C5aR and C3aR) and the Fcgamma receptor III (CD16), which recruit cells to inflammatory sites. While sharing with DC1 the expression of myeloid markers and a potent capacity to prime T cells in vitro, M-DC8+ DCs produce far more TNF-alpha in response to the bacterial endotoxin lipopolysaccharide (LPS). Thus, 6-sulfo LacNAc-expressing DCs appear as a novel proinflammatory DC subset.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-sulfo-LacNac,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Sugars,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/P-selectin ligand protein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Anaphylatoxin C5a,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/complement C3a receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-301
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12354382-Adult,
pubmed-meshheading:12354382-Amino Sugars,
pubmed-meshheading:12354382-Animals,
pubmed-meshheading:12354382-Antibodies, Monoclonal,
pubmed-meshheading:12354382-Antigens, CD,
pubmed-meshheading:12354382-Blood Cells,
pubmed-meshheading:12354382-Carbohydrate Conformation,
pubmed-meshheading:12354382-Carbohydrate Sequence,
pubmed-meshheading:12354382-Cell Movement,
pubmed-meshheading:12354382-Dendritic Cells,
pubmed-meshheading:12354382-E-Selectin,
pubmed-meshheading:12354382-Epitopes,
pubmed-meshheading:12354382-Glycosylation,
pubmed-meshheading:12354382-Humans,
pubmed-meshheading:12354382-Inflammation,
pubmed-meshheading:12354382-Lipopolysaccharides,
pubmed-meshheading:12354382-Membrane Glycoproteins,
pubmed-meshheading:12354382-Membrane Proteins,
pubmed-meshheading:12354382-Mice,
pubmed-meshheading:12354382-Mice, SCID,
pubmed-meshheading:12354382-Molecular Sequence Data,
pubmed-meshheading:12354382-P-Selectin,
pubmed-meshheading:12354382-Precipitin Tests,
pubmed-meshheading:12354382-Protein Processing, Post-Translational,
pubmed-meshheading:12354382-Receptor, Anaphylatoxin C5a,
pubmed-meshheading:12354382-Receptors, Complement,
pubmed-meshheading:12354382-Receptors, IgG,
pubmed-meshheading:12354382-Transplantation, Heterologous,
pubmed-meshheading:12354382-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells.
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pubmed:affiliation |
Institute of Immunology, Technical University of Dresden, Dresden, Germany.
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pubmed:publicationType |
Journal Article
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