Source:http://linkedlifedata.com/resource/pubmed/id/12352619
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
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| pubmed:dateCreated |
2002-9-27
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| pubmed:abstractText |
Interleukin-6 (IL-6) is a multifunctional cytokine playing a crucial role in inflammation and tissue injury. A role for this molecule in neurodegeneration and Alzheimer's disease (AD) has been proposed. The aim of this study was to evaluate the association between a common polymorphism of the IL-6 gene promoter and AD in the Italian population. We found that the frequency of the GG genotype was significantly higher in AD patients than controls on both univariate ( rho< 0.0001) and multivariate analysis ( rho< 0.0001). In contrast, the CC genotype seems to be associated with a reduced risk of disease ( rho< 0.0001). Our data indicate that the IL-6 gene polymorphism is associated with AD in Italians and confirm that IL-6 is crucial in the pathophysiology of neurodegenerative disorders.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0959-4965
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
16
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1645-7
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:12352619-Aged,
pubmed-meshheading:12352619-Alzheimer Disease,
pubmed-meshheading:12352619-Base Sequence,
pubmed-meshheading:12352619-Cytosine,
pubmed-meshheading:12352619-DNA Mutational Analysis,
pubmed-meshheading:12352619-Encephalitis,
pubmed-meshheading:12352619-Female,
pubmed-meshheading:12352619-Gene Frequency,
pubmed-meshheading:12352619-Genetic Predisposition to Disease,
pubmed-meshheading:12352619-Genetic Testing,
pubmed-meshheading:12352619-Genotype,
pubmed-meshheading:12352619-Guanine,
pubmed-meshheading:12352619-Humans,
pubmed-meshheading:12352619-Interleukin-6,
pubmed-meshheading:12352619-Italy,
pubmed-meshheading:12352619-Male,
pubmed-meshheading:12352619-Mutation,
pubmed-meshheading:12352619-Polymorphism, Genetic,
pubmed-meshheading:12352619-Promoter Regions, Genetic
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| pubmed:year |
2002
|
| pubmed:articleTitle |
The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer's disease in an Italian population [corrected].
|
| pubmed:affiliation |
Laboratory of Vascular Biology and Genetics, A Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, L.go A. Gemelli 8, 00168 Rome, Italy.
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| pubmed:publicationType |
Journal Article
|