Linked Life Data

1226435

Source:http://linkedlifedata.com/resource/pubmed/id/1226435

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1976-8-2
pubmed:abstractText
Rabbit hearts were perfused with bicarbonate-buffered fluid containing 1.0 mM glucose and 1.5 mM lactate. Pairs of redox substrates were measured in the perfusion fluid and the heart after perfusate concentrations of beta-hydroxybutyrate (beta-HB) and oxygen were varied. The perfusate lactate to pyruvate ratio was shown to accurately represent the tissue ratio. The intracellular redox state varied independently of changes in substrate uptake. Increasing perfusate beta-HB concentration caused increased beta-HB uptake, decreased lactate uptake, and unchanged glucose uptake. Decreased perfusate oxygen tension caused inhibition of lactate and beta-HB uptakes and, when exteme, caused increased glucose uptake. The combination of a modest reduction in oxygen tension and increased perfusate beta-HB concentration caused a more reduced environment in the tissue than either change by itself. This combination of changes may have additive deleterious effects as suggested by clinical observations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0363-5872
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Effects of changes in the concentrations of substrate and oxygen on the perfused rabbit heart.
pubmed:publicationType
Journal Article