12227119

Source:http://linkedlifedata.com/resource/pubmed/id/12227119

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011860, umls-concept:C0035820, umls-concept:C0596609, umls-concept:C1314792
pubmed:issue	3
pubmed:dateCreated	2002-9-13
pubmed:abstractText	The descriptive epidemiology of type 2 diabetes and findings from cohort studies suggest that this disorder originates in large part from a complex interaction between genetic and environmental factors. Determining the details of these interactions using the nested case-control design may be optimal, but is a long-term and expensive strategy. Quicker and cheaper results may be obtained by studying interaction on the quantitative traits that underlie diabetes; however, the power of such studies to detect interaction is highly dependent on the precision with which non-genetic exposures are measured. Unraveling these interactions will undoubtedly shed light on the etiology of diabetes and will, we hope, lead to opportunities for targeted prevention. Recent studies in high-risk groups such as people with impaired glucose tolerance suggest that the incidence of diabetes can be reduced by more than 50% by interventions aimed at changing dietary and physical activity behavior [39,40]; however, it may be that individuals with a particular genotype are particularly susceptible to the negative metabolic consequences of sedentary living, and that they conversely, therefore, would have most to gain from a targeted preventive intervention program. Understanding how to detect these individuals and which environmental factors a program should attempt to manipulate is a major goal of studies that attempt to unravel gene-environment interaction.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8800104
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0889-8529
pubmed:author	pubmed-author:FranksPaul WPW, pubmed-author:HardingAnne-HelenAH, pubmed-author:WarehamNicholas JNJ
pubmed:issnType	Print
pubmed:volume	31
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	553-66
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12227119-Diabetes Mellitus, Type 2, pubmed-meshheading:12227119-Genetic Predisposition to Disease, pubmed-meshheading:12227119-Humans
pubmed:year	2002
pubmed:articleTitle	Establishing the role of gene-environment interactions in the etiology of type 2 diabetes.
pubmed:affiliation	University of Cambridge, Department of Public Health and Primary Care, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK. njw1004@medschl.cam.ac.uk
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't