Source:http://linkedlifedata.com/resource/pubmed/id/12204801
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-9-2
|
| pubmed:abstractText |
Since inflammatory mechanisms seem to be involved in different stages of atherosclerosis, we analysed a random population-based sample of 972 subjects to assess the relationships between soluble intercellular adhesion molecule-1 (sICAM-1), subclinical peripheral atherosclerosis and intima-media thickness (IMT). B-mode ultrasonography was used to assess the presence of carotid (common and internal) and femoral atherosclerotic plaques and to measure common carotid IMT (avoiding plaque sites). Mean sICAM-1 level was 287.4 (standard deviation: 102.8) and 255.2 (83.5) ng/ml, respectively, in subjects with and without carotid plaques (P<0.0001). It equalled 286.7 (101.1) and 249.7 (79.7) ng/ml, respectively, in subjects with and without femoral plaques (P<0.0001). Subjects beyond the 90th percentile of common carotid IMT had higher sICAM-1 levels than those below, but this was not significant (P=0.08). Multiple logistic regression analyses adjusted for age, gender and other cardiovascular risk factors showed that sICAM-1 was independently associated with the risk of having at least one carotid plaque (adjusted odds ratio for a 10 ng/ml increase in sICAM-1: OR=1.03, 95% confidence interval: [1.02-1.05]) and with the risk of having at least one femoral plaque (adjusted OR=1.04 [1.02-1.06]). On the other hand, no significant relationship was found in multivariate analysis between sICAM-1 and common carotid IMT.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
164
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
297-304
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12204801-Adult,
pubmed-meshheading:12204801-Arteriosclerosis,
pubmed-meshheading:12204801-Biological Markers,
pubmed-meshheading:12204801-Carotid Artery, Common,
pubmed-meshheading:12204801-Carotid Artery, Internal,
pubmed-meshheading:12204801-Carotid Artery Diseases,
pubmed-meshheading:12204801-Cohort Studies,
pubmed-meshheading:12204801-Cross-Sectional Studies,
pubmed-meshheading:12204801-Female,
pubmed-meshheading:12204801-Femoral Artery,
pubmed-meshheading:12204801-Humans,
pubmed-meshheading:12204801-Intercellular Adhesion Molecule-1,
pubmed-meshheading:12204801-Logistic Models,
pubmed-meshheading:12204801-Male,
pubmed-meshheading:12204801-Middle Aged,
pubmed-meshheading:12204801-Multivariate Analysis,
pubmed-meshheading:12204801-Probability,
pubmed-meshheading:12204801-Prognosis,
pubmed-meshheading:12204801-Sampling Studies,
pubmed-meshheading:12204801-Sensitivity and Specificity,
pubmed-meshheading:12204801-Severity of Illness Index,
pubmed-meshheading:12204801-Solubility,
pubmed-meshheading:12204801-Tunica Media
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| pubmed:year |
2002
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| pubmed:articleTitle |
Soluble intercellular adhesion molecule-1 is associated with carotid and femoral atherosclerosis but not with intima-media thickness in a population-based sample.
|
| pubmed:affiliation |
Department of Epidemiology, INSERM U558, Faculté de Médecine, 37 allées Jules Guesde, 31 073 Cedex, Toulouse, France.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|