| pubmed-article:12200066 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12200066 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:12200066 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:12200066 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:12200066 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:12200066 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12200066 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12200066 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12200066 | pubmed:dateCreated | 2002-8-29 | lld:pubmed |
| pubmed-article:12200066 | pubmed:abstractText | Dendritic cells (DCs) are currently divided into tolerogenic immature and immunogenic mature differentiation stages. However, recent findings challenge this model by reporting mature DCs as inducers of regulatory CD4+ T cells in vivo. This implies that decisive tolerogenic and immunogenic maturation signals for DCs might exist. Closer inspection reveals that tolerance is observed when partial- or semi-maturation of DCs occurs, whereas only full DC maturation is immunogenic. The decisive immunogenic signal seems to be the release of proinflammatory cytokines from the DCs. Moreover, the semi-mature DC phenotype is comparable to steady-state migratory veiled DCs within the lymphatics, which seem to continuously tolerize lymph node T cells against tissue-derived self-antigens or apoptotic cells. | lld:pubmed |
| pubmed-article:12200066 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12200066 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12200066 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12200066 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12200066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12200066 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12200066 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12200066 | pubmed:issn | 1471-4906 | lld:pubmed |
| pubmed-article:12200066 | pubmed:author | pubmed-author:SchulerGerold... | lld:pubmed |
| pubmed-article:12200066 | pubmed:author | pubmed-author:LutzManfred... | lld:pubmed |
| pubmed-article:12200066 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12200066 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12200066 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12200066 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12200066 | pubmed:pagination | 445-9 | lld:pubmed |
| pubmed-article:12200066 | pubmed:dateRevised | 2005-8-31 | lld:pubmed |
| pubmed-article:12200066 | pubmed:meshHeading | pubmed-meshheading:12200066... | lld:pubmed |
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| pubmed-article:12200066 | pubmed:meshHeading | pubmed-meshheading:12200066... | lld:pubmed |
| pubmed-article:12200066 | pubmed:meshHeading | pubmed-meshheading:12200066... | lld:pubmed |
| pubmed-article:12200066 | pubmed:meshHeading | pubmed-meshheading:12200066... | lld:pubmed |
| pubmed-article:12200066 | pubmed:meshHeading | pubmed-meshheading:12200066... | lld:pubmed |
| pubmed-article:12200066 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12200066 | pubmed:articleTitle | Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? | lld:pubmed |
| pubmed-article:12200066 | pubmed:affiliation | University of Erlangen, Department of Dermatology, Hartmannstr. 14, 91052 Erlangen, Germany. lutz@derma.imed.uni-erlangen.de | lld:pubmed |
| pubmed-article:12200066 | pubmed:publicationType | Journal Article | lld:pubmed |
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