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pubmed-article:12199067pubmed:dateCreated2002-8-29lld:pubmed
pubmed-article:12199067pubmed:abstractTextIt was established, that serotonin and dopamine content and dopamine uptake by brain nerve endings under experimental parkinsonism are decreased. Nicotinamide nicotinoyl-GABA administration leads to normalization these parameters. It was shown that NAm was more effective on serotonin content while nicotinoyl-GABA on dopamine one. Dopamine uptake was impaired at experimental parkinsonism and partially was normalized by incubation with NAD (10(-6) M). Thus, NAm, nicotinoyl-GABA and NAD are involved in the regulation of brain neurotransmission under experimental parkinsonism and can be useful in treatment of Parkinson's disease.lld:pubmed
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pubmed-article:12199067pubmed:pagination108-12lld:pubmed
pubmed-article:12199067pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12199067pubmed:articleTitle[Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease].lld:pubmed
pubmed-article:12199067pubmed:affiliationPalladin Institute of Biochemistry, NAS of Ukraine, Kyiv. kuch@biochem.kiev.ualld:pubmed
pubmed-article:12199067pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12199067pubmed:publicationTypeEnglish Abstractlld:pubmed